AB5384

Anti-Nitric Oxide Synthase II Antibody

Name: Anti-Nitric Oxide Synthase II Antibody
Brand: MM

serum, Chemicon^®

Sinónimos:

NOS II, iNOS

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UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon^®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_000625.3
NM_153292.1

UniProt accession no.

P35228

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... NOS2(4843)

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Este artículo	AB1529	AB16301	ABN26
Sigma-Aldrich AB5384 Anti-Nitric Oxide Synthase II Antibody	Sigma-Aldrich AB1529 Anticuerpo anti-óxido nítrico sintasa I	Sigma-Aldrich AB16301 Anti-Nitric Oxide Synthase III Antibody	Sigma-Aldrich ABN26 Anticuerpo anti-iNOS/NOS II, NT
antibody form serum	antibody form serum	antibody form affinity purified immunoglobulin	antibody form affinity isolated antibody
biological source rabbit	biological source sheep	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) immunohistochemistry: suitable, western blot: suitable	technique(s) immunocytochemistry: suitable, western blot: suitable	technique(s) immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable, western blot: suitable
UniProt accession no. P35228	UniProt accession no. P29475	UniProt accession no. P29474	UniProt accession no. P29477

General description

The inducible isoform of the enzyme nitric oxide synthase (iNOS, NOS-II) is synthesized by macrophages and many other cell types in response to proinflammatory cytokines and certain other stimuli, such as hypoxia and stress.

Immunogen

C-terminal 19 amino acid peptide from human chondrocyte nitric oxide synthase.

Application

Detect Nitric Oxide Synthase II using this Anti-Nitric Oxide Synthase II Antibody validated for use in WB, IH.

Research Category
Neuroscience

Research Sub Category
Oxidative Stress

Western blot: 1:1,000-1:2,500 (ECL).

Immunohistochemistry: 1:2,500-1:6,000 (ABC).

Optimal working dilutions must be determined by end user.

Biochem/physiol Actions

Inducible nitric oxide synthase (iNOS, NOS-II). No cross-reaction with nNOS and eNOS by immunohistochemistry. AB5384 reacts with human glia and certain neurons in Alzheimer′s disease by immunohistochemistry.

Physical form

Rabbit serum. Liquid containing 0.05% sodium azide.

Preparation Note

Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Clase de almacenamiento

10 - Combustible liquids

wgk_germany

WGK 1

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Imaging pulmonary inducible nitric oxide synthase expression with PET.

Huang, HJ; Isakow, W; Byers, DE; Engle, JT; Griffin, EA; Kemp, D; Brody, SL; Gropler et al.

Journal of Nuclear Medicine null

Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.

Schuh, C; Wimmer, I; Hametner, S; Haider, L; Van Dam, AM; Liblau, RS; Smith, KJ; Probert et al.

Acta neuropathologica null

Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron.

Haider, L; Simeonidou, C; Steinberger, G; Hametner, S; Grigoriadis, N; Deretzi, G; Kovacs et al.

Journal of Neurology, Neurosurgery, and Psychiatry null

Provision of an explanation for the inefficacy of immunotherapy in sporadic inclusion body myositis: quantitative assessment of inflammation and β-amyloid in the muscle.

Jana Zschüntzsch et al.

Arthritis and rheumatism, 64(12), 4094-4103 (2012-09-04)

In sporadic inclusion body myositis (IBM), inflammation and accumulation of β-amyloid-associated molecules cause muscle fiber damage. We undertook this study to determine why intravenous immunoglobulin (IVIG) and prednisone are not effective in sporadic IBM despite their effectiveness in other inflammatory

The effects of human immunoglobulin G on enhancing tissue protection and neurobehavioral recovery after traumatic cervical spinal cord injury are mediated through the neurovascular unit.

Jonathon Chon Teng Chio et al.

Journal of neuroinflammation, 16(1), 141-141 (2019-07-11)

Spinal cord injury (SCI) is a condition with few effective treatment options. The blood-spinal cord barrier consists of pericytes, astrocytes, and endothelial cells, which are collectively termed the neurovascular unit. These cells support spinal cord homeostasis by expressing tight junction

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RABBIT ANTI-INDUCIBLE NITRIC OXIDE SYNTHASE (iNOS)

PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

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