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Merck

D4540

Sigma-Aldrich

Dimetilsulfóxido

≥99.5% (GC), suitable for plant cell culture

Dimethyl sulfoxide
1 of 2 reviewers received a sample product or took part in a promotion

Sinónimos:

DMSO

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100 ML
US$ 113,00
500 ML
US$ 208,00
1 L
US$ 303,00

US$ 113,00

PRECIOS SIN IMPUESTOS NACIONALES

Disponible para envío el20 de octubre de 2025Detalles

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Fórmula lineal:
(CH3)2SO
Número CAS:
67-68-5
Peso molecular:
78.13
Beilstein/REAXYS Number:
506008
EC Number:
200-664-3
MDL number:
MFCD00002089
UNSPSC Code:
12191502
PubChem Substance ID:
24893881
NACRES:
NA.71
Assay:
≥99.5% (GC)
Technique(s):
cell culture | plant: suitable
cryopreservation: suitable
Bp:
189 °C (lit.)
Vapor pressure:
0.42 mmHg ( 20 °C)

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vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

assay

≥99.5% (GC)

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

technique(s)

cell culture | plant: suitable
cryopreservation: suitable

impurities

<0.1% water (Karl Fischer)

color

colorless

refractive index

n20/D 1.479 (lit.)

bp

189 °C (lit.)

mp

16-19 °C (lit.)

solubility

H2O: miscible (completely)

density

1.10 g/mL (lit.)

SMILES string

CS(C)=O

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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Este artículo
D265301934D2438
Dimetilsulfóxido &#8805;99.5% (GC), suitable for plant cell culture

Sigma-Aldrich

D4540

Dimetilsulfóxido

Dimetilsulfóxido Hybri-Max&#8482;, 0.2 &#956;m filtered, BioReagent, suitable for hybridoma, &#8805;99.7%, Ampoule

Sigma-Aldrich

D2653

Dimetilsulfóxido

Dimetilsulfóxido for inorganic trace analysis, &#8805;99.99995% (metals basis)

Supelco

01934

Dimetilsulfóxido

Dimetilsulfóxido sterile-filtered, BioPerformance Certified, meets EP, USP testing specifications, suitable for hybridoma

Sigma-Aldrich

D2438

Dimetilsulfóxido

technique(s)

cell culture | plant: suitable, cryopreservation: suitable

technique(s)

cell culture | hybridoma: suitable, cryopreservation: suitable

technique(s)

-

technique(s)

cell culture | hybridoma: suitable, cryopreservation: suitable

assay

≥99.5% (GC)

assay

≥99.7%

assay

≥99.9% (GC), ≥99.99995% (metals basis)

assay

-

Quality Level

200

Quality Level

300

Quality Level

100

Quality Level

400

solubility

H2O: miscible (completely)

solubility

H2O: miscible (completely)

solubility

H2O: miscible (completely)

solubility

H2O: miscible (completely)

form

liquid

form

liquid

form

liquid

form

liquid

vapor density

2.7 (vs air)

vapor density

2.7 (vs air)

vapor density

2.7 (vs air)

vapor density

2.7 (vs air)

Application

El dimetilsulfóxido se ha utilizado:
  • en la preparación de bisfenol A (BPA)[1]
  • en ensayos de proliferación celular (ensayo de MTT)[2]
  • en ensayos de quimiosensibilidad[3]
  • como vehículo control en todos los experimentos como los análisis de apoptosis[4]
  • en el ensayo de la O-desetilación de la etoxiresorufina (EROD)[5]

Biochem/physiol Actions

El DMSO (dimetilsulfóxido), un disolvente orgánico, posee diversas actividades farmacéuticas, tales como efectos analgésicos, diuréticos, bacteriostáticos, antiinflamatorios, vasodilatadores e inhibidores de la colinesterasa, además de capacidad para penetrar a través de la membrana.[6] Es un producto secundario de la industria maderera y se utiliza como un disolvente industrial. El DMSO sirve también como agente terapéutico para tratar la cistitis intersticial y la artritis.[7]

Other Notes

Ganador del premio CiteAb 2024 como proveedor de éxito en la investigación del Parkinson

Disclaimer

Fácilmente superenfriado, vuelve a fundir lentamente a temperatura ambiente. Producto solidificado que puede volver a licuarse por calentamiento a temperatura ambiente sin detrimento del producto.

Clase de almacenamiento

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
SHBT3256
PCCS8446
SHBT1983
SHBT1986
SHBT1126

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Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Pharmacotherapy of joint and tendon disease
Equine Sports Medicine and Surgery E-Book: Basic and clinical sciences of the equine athlete, 473-473 (2013)
Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma
Hartojo W, et al.
Translational Oncology, 3(2), 99-108 (2010)
Evaluation of the sub-lethal toxicity of Cu, Pb, bisphenol A and polychlorinated biphenyl to the marine dinoflagellate Cochlodinium polykrikoides
Ebenezer V and Ki J S
Algae, 27(1), 63-63 (2012)
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells
Sanderson J T, et al.
Toxicological Sciences, 61(1), 40-48 (2001)
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Kuo C T, et al.
Biomaterials, 35(5), 1562-1571 (2014)
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Artículos

Good Cell Banking Practices

Overview of good cell banking practices for cell line cryopreservation purposes.

2 Reviews This action will navigate to reviews.

Questions

1–10 of 11 Questions  

  1. Can I use this product (suitable for plant cell culture) for cyropreservation of mammalian cells? Does cryopreservation of mammalian cells require sterile-filtered DMSO?

    1 answer

    1. D4540 is listed as suitable for cryopreservation.
      However, D2650 is already pre-sterile and has documentation with a protocol for cryopreservation of human and animal cell lines.

      See these links:
      https://www.sigmaaldrich.com/product/sigma/d2650
      https://www.sigmaaldrich.com/product/sigma/d2650#product-documentation

      Look for the Product Information Sheet. Also, see this link for more information:
      https://www.sigmaaldrich.com/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/cell-freezing-reagents

      Helpful?

  2. Can I autoclave this product?

    1 answer

    1. DMSO is not autoclavable in neat form. It is highly unlikely that microorganisms would survive in this environment. Should sterilization be necessary a PTFE, Polypropylene, or Nylon filter membrane are recommended for sterile-filtration.

      Helpful?

  3. Where does DMSO come from?

    1 answer

    1. DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.

      Helpful?

  4. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    1 answer

    1. DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

      Helpful?

  5. Does DMSO have any synthetic utility?

    1 answer

    1. DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.

      Helpful?

  6. What is the molarity of DMSO?

    1 answer

    1. DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

      Helpful?

  7. What is the DMSO dissolved in?

    1 answer

    1. DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.

      Helpful?

  8. What concentration of DMSO do I use in a cell freezing media?

    1 answer

    1. DMSO is usually used at 1-10%, depending on the cell line.  For the cell freezing media that we offer, it is used at 8.7% concentration.

      Helpful?

  9. Is Dimethyl sulfoxide a sterile product?

    1 answer

    1. No, this product is not considered sterile.  Product Nos. D2560 and D2438 are sterile-filtered.

      Helpful?

  10. What type of filter is used to sterile-filter Dimethyl sulfoxide (DMSO)?

    1 answer

    1. DMSO can be sterile-filtered through a 0.2 micron PTFE filter. The sterility testing is per the current US Pharmacopoeia method.

      Helpful?

1–10 of 11 Questions  
2 Reviews This action will navigate to reviews.
1 of 2 reviewers received a sample product or took part in a promotion
1 out of 1 (100%) reviewers recommend this product

Reviews

Active Filters

  1. San Diego
    • Review 1
    • Votes 4
    5 out of 5 stars.

    Works on mammalian cells

    Good for mammalian cell culture treatments of compound

    Helpful?

  2. 1 Ratings-only review

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