O7389

Olprinone hydrochloride

Name: Olprinone hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Sinónimos:

1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride, Loprinone hydrochloride

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Fórmula empírica (notación de Hill):

C₁₄H₁₀N₄O · HCl

Número CAS:

119615-63-3

Peso molecular:

286.72

NACRES:

NA.77

PubChem Substance ID:

24724566

UNSPSC Code:

41106305

MDL number:

MFCD01749474

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Nombre del producto

Olprinone hydrochloride, ≥98% (HPLC), solid

InChI

1S/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H

SMILES string

Cl[H].CC1=C(C=C(C#N)C(=O)N1)c2ccc3nccn3c2

InChI key

PWTBMBAQRAOAFF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

beige

solubility

DMSO: ≤4 mg/mL
H₂O: 6.8 mg/mL

storage temp.

2-8°C

Biochem/physiol Actions

Selective phosphodiesterase 3 (PDE3) inhibitor.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number

056K47151

056K4715

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Intermittent infusions of carperitide or inotoropes in out-patients with advanced heart failure.

Kiyoto Nishi et al.

Journal of cardiology, 59(3), 366-373 (2012-03-01)

The ambulatory treatment of advanced heart failure (HF) with intermittent infusions of inotropes or natriuretic peptide chosen immediately before each infusion has not been described. Between May 2005 and July 2009, we treated 11 patients presenting with advanced HF, who

[Effect of landiolol and combined use of landiolol and olprinone on hemodynamics in patients undergoing off-pump coronary artery bypass grafting].

Mayumi Tachikawa et al.

Masui. The Japanese journal of anesthesiology, 61(6), 566-573 (2012-07-04)

Beta blockers are frequently used to reduce cardiac oxygen demand in off-pump coronary artery bypass grafting (OPCAB). However, significant bradycardia or negative inotropic effects are seen on occasion. We hypothesized that combined use of landiolol (L), an ultra short-acting beta

Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway.

Hirofumi Oishi et al.

American journal of physiology. Lung cellular and molecular physiology, 303(2), L130-L140 (2012-05-23)

Olprinone, a specific phosphodiesterase III inhibitor, and corforsin daropate, a direct adenylate cyclase activator, are now being used in critical conditions. We investigated whether their therapeutic use provides protection against septic acute lung injury (ALI) and mortality. Polymicrobial sepsis was

Reversal of oxidant-mediated biochemical injury and prompt functional recovery after prolonged single-dose crystalloid cardioplegic arrest in the infantile piglet heart by terminal warm-blood cardioplegia supplemented with phosphodiesterase III inhibitor.

Katsushi Kinouchi et al.

General thoracic and cardiovascular surgery, 60(2), 73-81 (2012-02-14)

The benefit of terminal blood cardioplegia (TWBCP) is insufficient after prolonged ischemia associated with inevitable oxidant-mediated injury by this modality alone. We tested the effects of TWBCP supplemented with high-dose olprinone, which is a phosphodiesterase III inhibitor, a clinically available

Effect of olprinone, a phosphodiesterase III inhibitor, on balance of cerebral oxygen supply and demand during cardiopulmonary bypass.

Hiroo Yamanaka et al.

Journal of cardiovascular pharmacology, 57(5), 579-583 (2011-02-18)

Neuropsychological dysfunction with cardiopulmonary bypass (CPB) may be facilitated by inadequate cerebral oxygen balance during CPB. Olprinone, a phosphodiesterase III inhibitor, augments cerebral blood flow by a direct vasodilator effect on cerebral arteries. We conducted the present randomized study in

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