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Merck

CHRM2

cholinergic receptor, muscarinic 2

Synonyme:
HM2
Spezies:
Human CHRM2 (1129), Mouse Chrm2 (243764), Rat Chrm2 (81645), Domestic Rabbit CHRM2 (100342878), naked mole-rat Chrm2 (101714286), chicken CHRM2 (418126), domestic guinea pig Chrm2 (100715343), dog CHRM2 (403858), cow CHRM2 (522170), domestic cat CHRM2 (101099790) ...Mehr
UniProtKB-ID:
P08172, Q4VBK6, Q9P1X9
Gen-ID:
  • Human(1129) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(243764) cholinergic receptor, muscarinic 2, cardiac
  • Rat(81645) cholinergic receptor, muscarinic 2
  • Domestic Rabbit(100342878) cholinergic receptor, muscarinic 2
  • naked mole-rat(101714286) cholinergic receptor, muscarinic 2
  • chicken(418126) cholinergic receptor, muscarinic 2
  • domestic guinea pig(100715343) cholinergic receptor, muscarinic 2
  • dog(403858) cholinergic receptor, muscarinic 2
  • cow(522170) cholinergic receptor, muscarinic 2
  • domestic cat(101099790) cholinergic receptor, muscarinic 2
  • sheep(101102897) cholinergic receptor, muscarinic 2
  • sheep(100628317) cholinergic receptor, muscarinic 2

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Small Molecule - Agonist

Produktnummer
Beschreibung
Spezies
P6503
Pilocarpin -hydrochlorid, ≥99% (titration), powder,
Spezies
human
A2251
Acetyl-β-Methylcholin-Chlorid, ≥98% (TLC), powder,
Spezies
human
P6628
Pilocarpin -nitrat (Salz), ≥98% (HPLC),
Spezies
human
O100
Oxotremorine M, solid,
Spezies
human
M104
(±)-Muscarine chloride hydrate, ≥98% (HPLC),
Spezies
human

Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
M105
Methoctramine hydrate, ≥97% (NMR), solid,
Spezies
human
SML1102
Darifenacin hydrobromide, ≥98% (HPLC),
Spezies
human
O5015
Oxybutyninchlorid, meets EP, USP testing specifications,
Spezies
human
1485103
Oxybutyninchlorid, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
O0288000
Oxybutynin -hydrochlorid, European Pharmacopoeia (EP) Reference Standard,
Spezies
human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
MAB367
Anti-muscarinischer-Acetylcholinrezeptor-m2-Antikörper, Klon M2-2-B3, clone M2-2-B3, Chemicon®, from rat,
Speziesreaktivität
human, mammals, monkey, rat
Anwendung
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
AB9452
Anti-Muscarinic Acetylcholine Receptor M2 Antibody, Chemicon®, from rabbit,
Speziesreaktivität
human
Anwendung
immunohistochemistry
WH0001129M1
Monoclonal Anti-CHRM2 antibody produced in mouse, clone 4B5, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
western blot
SAB1405619
Anti-CHRM2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
western blot

Small Molecule - Inhibitor

Produktnummer
Beschreibung
Spezies
A8404
Amitriptylin -hydrochlorid, ≥98% (TLC), powder,
Spezies
human
D4526
Doxepin -hydrochlorid, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Spezies
human
H1512
Haloperidol, powder,
Spezies
human, rat
51330
Harmalin, ≥95%,
Spezies
human, rat

Small Molecule - Ligand

Produktnummer
Beschreibung
Spezies
A138
Aminobenztropine, solid,
Spezies
human

Proteins

Produktnummer
Beschreibung
Spezies
HTS115M
ChemiSCREEN Membrane Preparation Recombinant Human M2 Muscarinic Acetylcholine Receptor, Human M2 GPCR membrane prepation for Radioligand binding Assays.,
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
EHU120771
MISSION® esiRNA, targeting human CHRM2,
Spezies
human