O100

Oxotremorine M

muscarinic acetylcholine receptor agonist, solid

• Synonym(e): N,N,N,-Trimethyl-4-(2-oxo-1-pyrrolidinyl)-2-butyn-1-ammonium iodide, Oxotremorine methiodide
• Empirische Formel (Hill-System): C₁₁H₁₉IN₂O
• CAS-Nummer: 63939-65-1
• Molekulargewicht: 322.19
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277861
• NACRES: NA.77
• MDL number: MFCD00055133
• Form: solid

Eigenschaften

• Produktname: Oxotremorine M, solid
• form: solid
• Quality Segment: 200
• color: white
• solubility: H₂O: 24 mg/mL, ethanol: 4.6 mg/mL
• storage temp.: 2-8°C
• SMILES string: [I-].C[N+](C)(C)CC#CCN1CCCC1=O
• InChI: 1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1
• InChI key: VVLMSCJCXMBGDI-UHFFFAOYSA-M
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Beschreibung

Application

Oxotremorine M has been used as a muscarinic acetylcholine receptor (mAchR) agonist:

• to study its acute effects on the movement of Caenorhabditis elegans
• to treat hippocampal neurons for studying fibroblast growth factor receptor 1 (FGFR1) phosphorylation
• to induce bladder overactivity in rats

Biochem/physiol Actions

Oxotremorine M is a nonselective muscarinic acetylcholine receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) and Acetylcholine Receptors (Nicotinic) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H300 + H310 + H330
• Sicherheitshinweise: P260 - P262 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type N95 (US)