This product is not tested for Nitrosamine content. This product is research use only. Test specifications for this product is listed on the lot-specific Certificate of Analysis. Please navigate to the ‘DOCUMENTATION’ section of the Product Detail Page to access a Certificate under ‘Certificate of Analysis’:
https://www.sigmaaldrich.com/product/sigma/a8404#product-documentation
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A8404
Amitriptylin -hydrochlorid
≥98% (TLC), norepinephrine and serotonin transporter inhibitor, powder
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| Größe/SKU | Verfügbarkeit | Preis |
|---|---|---|
10 g | Warenkorb auf Verfügbarkeit prüfen | € 44,00 |
25 g | Warenkorb auf Verfügbarkeit prüfen | € 90,40 |
100 g | Warenkorb auf Verfügbarkeit prüfen | € 249,00 € 211,65 |
250 g | Warenkorb auf Verfügbarkeit prüfen | € 397,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C20H23N · HCl
CAS-Nummer:
Molekulargewicht:
313.86
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-964-6
MDL number:
Assay:
≥98% (TLC)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenProduktname
Amitriptylin -hydrochlorid, ≥98% (TLC), powder
Quality Segment
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: soluble, ethanol: soluble
originator
Bristol-Myers Squibb
storage temp.
2-8°C
SMILES string
Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13
InChI
1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H
InChI key
KFYRPLNVJVHZGT-UHFFFAOYSA-N
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), SLC6A2(6530), SLC6A4(6532)
Application
Amitriptyline hydrochloride has been used:
- as an antidepressant to study its effects on social behavior and memory in transgenic for acid sphingomyelinase (t-ASM) mice
- as a tricyclic antidepressant to analyze its effects on glucocorticoid receptor function in whole human blood
- as an anti-depressant to study its effects on scratching and locomotion behavior in chloroquine-induced mouse
Biochem/physiol Actions
Amitriptyline hydrochloride shows therapeutic effects against anxiety, maniac depression, and involutional melancholia. It possesses antihistaminic, anticholinergic, and antiserotonimic properties. Amitriptyline hydrochloride acts as an amphiphilic agent and exhibits neuroleptic activity.
Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
Tricyclic antidepressant; norepinephrine and serotonin transporter inhibitor; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
Features and Benefits
Shelf-life of the powder is at least three years.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (TLC), powder | description ≥98% (TLC), powder | description ≥98% (TLC), solid | description A mobile ion-carrier that forms stable complexes with divalent cations. |
| assay ≥98% (TLC) | assay ≥98% (TLC) | assay ≥98% (TLC) | assay ≥98% (TLC) |
| form powder | form powder | form solid | form solid |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. - | storage temp. 2-8°C |
| solubility ethanol: soluble, H2O: soluble | solubility ethanol: soluble, H2O: soluble | solubility ethanol: soluble, methanol: soluble | solubility methanol: soluble, DMSO: soluble |
| originator Bristol-Myers Squibb | originator Merck & Co., Inc., Kenilworth, NJ, U.S. | originator Merck & Co., Inc., Kenilworth, NJ, U.S. | originator - |
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Signalwort
Danger
Gefahrencodes
Sicherheitshinweise
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2
Lagerklasse
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Was ist los?
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
PSA (Persönliche Schutzausrüstung)
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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is this standard tested for Nitrosamine content (NDMA)?
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