02252

(−)-Epinephrin

tested according to USP

• Synonym(e): (−)-Adrenalin, (R)-(−)-3,4-Dihydroxy-α-(methylaminomethyl)-benzylalkohol, L-Adrenalin, L-Epinephrin
• Lineare Formel: (HO)₂C₆H₃CH(OH)CH₂NHCH₃
• CAS-Nummer: 51-43-4
• Molekulargewicht: 183.20
• EC Number: 200-098-7
• UNSPSC Code: 12352200
• PubChem Substance ID: 24845246
• Beilstein/REAXYS Number: 2368277
• MDL number: MFCD00002204

Eigenschaften

• agency: tested according to USP
• mp: 215 °C (dec.) (lit.)
• solubility: H₂O: very slightly soluble, NaOH: very soluble, acetone: insoluble, alcohol: very slightly soluble, chloroform: insoluble, diethyl ether: insoluble, oil: insoluble, potassium hydroxide solution: very soluble
• application(s): pharmaceutical (small molecule)
• storage temp.: 2-8°C
• SMILES string: CNC[C@H](O)c1ccc(O)c(O)c1
• InChI: 1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
• InChI key: UCTWMZQNUQWSLP-VIFPVBQESA-N
• Gene Information: rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Adrb2(24176), Drd1a(24316), Drd2(24318)

Beschreibung

Application

(-)-Epinephrine was used in fertilization medium for rinsing Cumulus-oocyte complexes (COC) during in vitro maturation.

Biochem/physiol Actions

(-)-Epinephrine enhances the IL-6 secretion and bioactivity from isolated perfused rat liver (IPRL).

Adrenoceptor-Agonist

Preparation Note

(-)-Epinephrine readily dissolves in aqueous solutions of mineral acids, KOH and NaOH. It is very slightly soluble in water and alcohol but is insoluble in chloroform, ether, acetone, oils as well as in aqueous solutions of ammonia and the alkali carbonates.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301 + H331,H310
• Sicherheitshinweise: P261 - P262 - P280 - P301 + P310 - P302 + P352 + P310 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 2 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges