A1987

AM6545

≥98% (HPLC)

• Synonym(e): 5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide
• Empirische Formel (Hill-System): C₂₆H₂₃Cl₂N₅O₃S
• CAS-Nummer: 1245626-05-4
• Molekulargewicht: 556.46
• NACRES: NA.77
• PubChem Substance ID: 329770727
• UNSPSC Code: 12352200
• MDL number: MFCD19053178
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >25 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(cc3)C#CCCC#N)C(=O)NN4CCS(=O)(=O)CC4
• InChI: 1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34)
• InChI key: XBHQLFVDGLPBCK-UHFFFAOYSA-N

Beschreibung

General description

AM6545 is a cannabinoid (CB1) receptor antagonist.

Biochem/physiol Actions

AM6545 is a peripheral CB1 cannabinoid receptor antagonist and appetite suppressant.

AM6545 helps in decreasing the development of albuminuria, inflammation and expression of markers of fibrosis. It also helps in the down-regulation of nephrin and podocin. It has the ability to repress the ingestion of food and food-reinforced behaviour.

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H319
• Sicherheitshinweise: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable