A7015

N-(2-Fluorenyl)acetamid

≥98% (HPLC)

• Synonym(e): 2-Acetamino-fluoren
• Empirische Formel (Hill-System): C₁₅H₁₃NO
• CAS-Nummer: 53-96-3
• Molekulargewicht: 223.27
• UNSPSC Code: 12352103
• NACRES: NA.25
• PubChem Substance ID: 24891166
• EC Number: 200-188-6
• Beilstein/REAXYS Number: 2807677
• MDL number: MFCD00001116
• eCl@ss: 32150312

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• mp: 192-196 °C (lit.)
• SMILES string: CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1
• InChI: 1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)
• InChI key: CZIHNRWJTSTCEX-UHFFFAOYSA-N

Beschreibung

Application

N-(2-Fluorenyl)acetamide (2-Acetamidofluorene, 2-AAF), a genotoxic carcinogen, is used to induce liver cancer in animal models such as the 2-AAF/partial hepatectomy rat. 2-AAF may be used to study the mechanism of liver carcinogenesis and as a reference material during its identification or quantitation.

Biochem/physiol Actions

A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• Gefahrencodes: H302,H350
• Sicherheitshinweise: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type P2 (EN 143) respirator cartridges