B2640

DL-Buthionin-(S,R)-Sulfoximin

synthetic (organic), ≥98% (TLC), γ-glutamylcysteine synthetase inhibitor, powder

• Lineare Formel: CH₃(CH₂)₃S(O)(=NH)CH₂CH₂CH(NH₂)CO₂H
• CAS-Nummer: 5072-26-4
• Molekulargewicht: 222.31
• UNSPSC Code: 12161501
• PubChem Substance ID: 24278264
• NACRES: NA.77
• MDL number: MFCD00070309
• Assay: ≥98% (TLC)
• Form: powder

Eigenschaften

• Produktname: DL-Buthionin-(S,R)-Sulfoximin,
• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• mp: 215 °C (dec.) (lit.)
• solubility: water: 50 mg/mL, clear to very slightly hazy, colorless to yellow
• storage temp.: 2-8°C
• SMILES string: CCCCS(=N)(=O)CCC(N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
• InChI key: KJQFBVYMGADDTQ-UHFFFAOYSA-N

Beschreibung

General description

DL-buthionine-SR-sulfoximine (BSO) is an amino acid analogue, which acts as an inhibitor of γ-glutamylcysteine synthetase. BSO increases the sensitivity of Trypanosoma cruzi to antiparasitic drugs, such as nifurtimox or benznidazole.

Application

DL-Buthionine-(S,R)-sulfoximine has also been used:

• to induce oxidative stress in Starlings
• to deplete choroidal glutathione (GSH) in two-day-old rat pups
• to test its inhibitory effect on the enzymes, γ-glutamylcysteine synthetase and trypanothione synthetase (TryS) from T. cruzi

DL-Buthionine-(S,R)-sulfoximine has been used to deplete cellular glutathione levels in retinal ganglion cell 5 (RGC-5) cell line.

Biochem/physiol Actions

Depletes cellular glutathione and downregulates GST level.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves