C9033

β-Chlor-L-Alanin -hydrochlorid

Alanine aminotransferase inhibitor

• Synonym(e): (R)-2-Amino-3-chloropropanoic acid, 3-Chloro-L-alanine
• Empirische Formel (Hill-System): C₃H₆ClNO₂ · HCl
• CAS-Nummer: 51887-89-9
• Molekulargewicht: 160.00
• NACRES: NA.32
• PubChem Substance ID: 24278345
• UNSPSC Code: 12352204
• MDL number: MFCD00070398
• eCl@ss: 32160703

Eigenschaften

• biological source: synthetic
• Quality Segment: 200
• assay: ≥98% (TLC)
• form: powder
• mp: 205 °C
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: Cl[H].N[C@@H](CCl)C(O)=O
• InChI: 1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m0./s1
• InChI key: IENJPSDBNBGIEL-DKWTVANSSA-N

Beschreibung

Application

β-Chloro-L-alanine hydrochloride has been used:

• as a substrate for screening tyrosine phenol lyase steady state kinetics
• in the inhibition of serine palmitoyltransferase and cytotoxicity studies in lymphocyte Ly-1 cells
• as an inhibitor of alanine transaminase in wheat germ cell-free protein synthesis system

Biochem/physiol Actions

β-Chloro-L-alanine hydrochloride is an inhibitor of alanine aminotransferase (ALAT). Inhibition of ALAT leads to suppression of tumor progression in lung carcinoma.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H315,H319,H335
• Sicherheitshinweise: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): dust mask type N95 (US), Eyeshields, Gloves