F4765

Fluphenazin -dihydrochlorid

• Synonym(e): 4-[3-[2-(Trifluormethyl)-10H-phenothiazin-10-yl]-propyl]-1-piperazinethanol
• Empirische Formel (Hill-System): C₂₂H₂₆F₃N₃OS · 2HCl
• CAS-Nummer: 146-56-5
• Molekulargewicht: 510.44
• NACRES: NA.77
• PubChem Substance ID: 57654184
• UNSPSC Code: 12352200
• EC Number: 205-674-1
• MDL number: MFCD00055212

Eigenschaften

• SMILES string: Cl.Cl.OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
• InChI: 1S/C22H26F3N3OS.2ClH/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29;;/h1-2,4-7,16,29H,3,8-15H2;2*1H
• InChI key: MBHNWCYEGXQEIT-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), HRH1(3269)

Beschreibung

General description

Fluphenazine may be useful for the treatment of schizophrenia.

Application

Fluphenazine dihydrochloride has been used:

• to study its effects as a drug on glioblastoma (GBM) cells
• in fluorescence-activated cell sorting (FACS) analysis, sorting and single-cell stress-survival experiments
• to study its exposure effects on learning and memory in adult rats

Biochem/physiol Actions

D₁/D₂ dopamine receptor antagonist; phenothiazine antipsychotic; H₁ histamine receptor antagonist.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• Gefahrencodes: H301,H360
• Sicherheitshinweise: P201 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 1A
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable