SML0208

KYP-2047

≥95% (HPLC), Prolyl oligopeptidase inhibitor, oil

• Synonym(e): (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
• Empirische Formel (Hill-System): C₂₀H₂₅N₃O₂
• CAS-Nummer: 796874-99-2
• Molekulargewicht: 339.43
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825230
• NACRES: NA.77
• MDL number: MFCD22201003
• eCl@ss: 32150313
• Assay: ≥95% (HPLC)
• Form: oil
• Storage condition: desiccated

Eigenschaften

• Produktname: KYP-2047, ≥95% (HPLC)
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: oil
• storage condition: desiccated
• color: white to light brown
• storage temp.: 2-8°C
• SMILES string: O=C(CCCc1ccccc1)N2CCC[C@H]2C(=O)N3CCC[C@H]3C#N
• InChI: 1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1
• InChI key: SPXFAUXQZWJGCJ-ROUUACIJSA-N

Beschreibung

Application

KYP-2047 may be used in prolyl endopeptidase-mediated cell signaling studies.

Biochem/physiol Actions

KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine).

KYP-2047 is a very potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = .023nM (porcine). KYP-2047 has been found to be neuroprotective against glutamate and oxygen, glucose deprivation in vitro. It has also been used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.

KYP-2047 clears the α-synuclein aggregates induced by oxidative stress in the neuronal cells. α-synuclein is the main component of Lewy bodies in Parkinson′s disease that cause neuronal cell death and dementia.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H319
• Sicherheitshinweise: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable