SML1548

THPN

≥98% (HPLC)

• Synonym(e): 1-(2,4,6-Trihydroxyphenyl)-1-nonanone, 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, CID 3063200
• Empirische Formel (Hill-System): C₁₅H₂₂O₄
• CAS-Nummer: 100079-26-3
• Molekulargewicht: 266.33
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825957
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=C(O)C(O)=CC(C(CCCCCCCC)=O)=C1
• InChI: 1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3
• InChI key: NVFRHTFJDGAFQS-UHFFFAOYSA-N

Beschreibung

General description

THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B.

Biochem/physiol Actions

THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma.

THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model.

Other Notes

air sensitive

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable