SML1624

JNJ-63533054

≥98% (HPLC)

• Synonym(e): (S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)benzamide
• Empirische Formel (Hill-System): C₁₇H₁₇ClN₂O₂
• CAS-Nummer: 1802326-66-4
• Molekulargewicht: 316.78
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -89 to -99°, c = 1 in ethanol
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: room temp
• SMILES string: Clc1cc(ccc1)C(=O)NCC(=O)N[C@@H](C)c2ccccc2
• InChI key: MWDVCHRYCKXEBY-LBPRGKRZSA-N

Beschreibung

Biochem/physiol Actions

JNJ-63533054 is a potent and selective agonist of the orphan receptor hGPR139, a GPCR receptor expressed in the brain in circumventricular regions of the habenula and septum. JNJ-63533054 has an EC50 value of 16 nM, crosses the blood-brain barrier, and is orally available.

Potent and selective agonist of hGPR139 with an EC50 value of 16 nM

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H315,H319
• Sicherheitshinweise: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable