Ganciclovir

Name: Ganciclovir
Brand: SIGMA

≥99% (HPLC), DMSO solution, viral DNA elongation inhibitor

Synonym(e):

Ganciclovir ready made solution, 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, DHPG

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Empirische Formel (Hill-System):

C₉H₁₃N₅O₄

CAS-Nummer:

82410-32-0

Molekulargewicht:

255.23

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD12197280

Assay:

≥99% (HPLC)

Form:

DMSO solution

Technischer Dienst

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Eigenschaften

Produktname

Ganciclovir ready made solution, ≥99% (HPLC), 10 mM in DMSO

assay

≥99% (HPLC)

form

DMSO solution

concentration

10 mM in DMSO

storage temp.

2-8°C

SMILES string

[n]1(c2[nH]c(n[c](c2nc1)=O)N)COC(CO)CO

InChI

1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)

InChI key

IRSCQMHQWWYFCW-UHFFFAOYSA-N

Beschreibung

Application

Ganciclovir ready-made solution has been used in combination with resveratrol to study its effect on melanoma cells. It has also been used as a synthetic substrate for viral thymidine kinase to study its effects on human-inducible pluripotent stem cells.

Biochem/physiol Actions

Ganciclovir is a nucleoside guanosine analog that contains an active moiety, ganciclovir triphosphate. This active moiety can inhibit viral replication by interrupting the viral DNA during elongation. Ganciclovir is a potent agent in preventing cytomegalovirus (CMV) retinitis disease in human immunodeficiency virus (HIV) patients. It exhibits therapeutic effects against CMV disease involving the lungs, liver, and gastrointestinal tract. Ganciclovir can be enzymatically phosphorylated to an active triphosphate analog by herpes simplex virus thymidine kinase (HSV-TK) or host-encoded deoxyguanosine kinase. It has the potential to treat allogeneic bone marrow, kidney, heart, liver, and lung transplantations.

Other Notes

Ganciclovir ready made solution in DMSO is provided at 10mM concentration (2.55mg/mL). It is suggested to dilute the provided ready made solution to a working concentration of 2-100μM for cell culture applications.