SML4239

Phenoxodiol

≥98% (HPLC), powder, tNOX (ENOX2) inhibitor

• Synonym(e): 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol; 3-(4-Hydroxyphenyl)-2H-benzopyran-7-ol, Haginin E, Idronoxil, Dehydroequol, NV 06
• Empirische Formel (Hill-System): C₁₅H₁₂O₃
• CAS-Nummer: 81267-65-4
• Molekulargewicht: 240.25
• MDL number: MFCD06636630
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to pink
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Application

Phenoxodiol may be used to study immunomodulatory effects on human peripheral blood mononuclear cells in in vitro and in vivo assays.

Biochem/physiol Actions

Phenoxodiol, an isoflavene, is a broad-spectrum anti-tumor agent that causes apoptosis via both intrinsic and extrinsic pathways. It is a pan-cancer drug that targets plasma membrane electron transport (PMET). It also acts as a potent sensitizer of most standard chemotoxic agents. Phenoxodiol inhibits tumor-specific NADH oxidase tNOX (ENOX2) and DNA topoisomerase II. It blocks phosphorylation and activation of several different pro-survival signaling proteins including sphingosine kinase and Akt. It is also known to inhibit tyrosine kinases and X-linked inhibitor of apoptosis.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• Gefahrencodes: H302,H400
• Sicherheitshinweise: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): No data available
• Flammpunkt (°C): No data available