SML4281

Ynamide 2e

≥97% (NMR), oil

• Synonym(e): N-Ethynyl-1,1,1-trifluoro-N-(2-hydroxyethyl)methanesulfonamidel
• Empirische Formel (Hill-System): C₅H₆F₃NO₃S
• CAS-Nummer: 2672545-22-9
• Molekulargewicht: 217.17
• UNSPSC Code: 12352203
• Assay: ≥97% (NMR)
• Form: oil

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (NMR)
• form: oil
• color: colorless to yellow
• storage temp.: -10 to -25°C

Beschreibung

Application

Ynamide 2e is suitable for use in the modification of Cys-containing proteins and antibodies.

Biochem/physiol Actions

Ynamide-2e, featuring a N-trifyl group, provides a highly efficient and chemoselective method for cysteine-specific modification in peptides and proteins. Ynamide-2e exclusively forms Z-isomer conjugates with superior stability under various conditions. This bioconjugation tool exhibits excellent thiol specificity, with a second-order rate constant of 0.2399 M−1 s−1 for glutathione, outperforming traditional reagents like iodoacetamide in reducing off-target labeling. Functioning efficiently in aqueous buffer, Ynamide-2e is compatible with a wide range of proteins, including antibodies, without compromising protein integrity or function. Its applicability in bottom-up proteomics workflows and potential for redox proteomics make it valuable for studying protein modifications and interactions.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• Gefahrencodes: H301
• Sicherheitshinweise: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable