SML4353

JNJ-9350

≥97% (HPLC)

• Synonym(e): JNJ 9350, JNJ9350, N- (3-(1H-Imidazol-1-yl)propyl)-5, 7-diphenylpyrazolo[1, 5-a]pyrimidine-2-carboxamide
• Empirische Formel (Hill-System): C₂₅H₂₂N₆O
• CAS-Nummer: 326923-09-5
• Molekulargewicht: 422.48
• UNSPSC Code: 12352200
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

JNJ-9350 is a potent and selective spermine oxidase (SMOX) inhibitor (IC50 = 10 nM/SMOX, 739 nM/PAOX) that exhibits 20-times higher cellular SMOX engagement efficacy than MDL72527 (IC50 = 1.2 µM vs 23.7 µM by celluar thermal shift assay using A549 cells).

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable