SML4383

ALKBH1-IN-16

≥98% (HPLC)

• Synonym(e): DNA 6mA Demethylase ALKBH1 Inhibitor 16, N-Hydroxy-1-(5-((3-(trifluoromethoxy)benzyl)oxy)pyrimidin-2-yl)-1H-pyrazole-4-carboxamide
• Empirische Formel (Hill-System): C₁₆H₁₂F₃N₅O₄
• Molekulargewicht: 395.29
• UNSPSC Code: 12352200
• eCl@ss: 32160701
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

ALKBH1-IN-16 is a cell-permeant hydroxamate analog that effectively competes with α-KG to suppress ALKBH1 (KD = 3.27 µM and IC50 = 1.696 µM), a DNA demethylase. By engaging ALKBH1, ALKBH1-IN-16 prevents its interaction with DNA, increasing N6-Methyladenine (6mA) levels in cellular DNA and mimicking the effects of ALKBH1 suppression on gene regulation and signaling. Furthermore, ALKBH1-IN-16 inhibits the growth of U251 brain cancer cells (IC50 = 12.92 µM) and, at higher doses, targets COX-2, HDAC2, and HDAC7 (IC50 = 1.45, 8.74, and 18.62 µM, respectively), showcasing its wider inhibitory impact on enzymes linked to inflammation and gene expression.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable