SML4416

Tildipirosin

≥98% (HPLC)

• Synonym(e): 20-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-β-D-glucopyranosyl]-20,23-di-1-piperidinyltylonolide
• Empirische Formel (Hill-System): C₄₁H₇₁N₃O₈
• CAS-Nummer: 328898-40-4
• Molekulargewicht: 734.02
• UNSPSC Code: 12352200
• eCl@ss: 32160702
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Tildipirosin, a cell-permeable macrolide antibiotic, shows enhanced efficacy against key Gram-negative respiratory pathogens like Mannheimia haemolytica and Pasteurella multocida through improved outer membrane penetration. Selectively inhibits bacterial protein synthesis (IC50 ~0.23 µM) by binding the 23S rRNA of the 50S bacterial ribosomal subunit, blocking peptide chain prolongation and disrupting vital functions, yielding bacteriostatic or bactericidal effects with typical MIC90 values of 0.5-4 µg/ml. This mechanism enables effective treatment and metaphylaxis of Bovine (BRD) and Swine Respiratory Diseases (SRD), often as a single dose due to its long duration of action. Tildipirosin also displays immunomodulatory and anti-inflammatory actions by inhibiting pro-inflammatory cytokine secretion. Its significance is providing a targeted, long-acting therapeutic for critical veterinary respiratory infections.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• Gefahrencodes: H317,H361d,H373
• Sicherheitshinweise: P202 - P260 - P272 - P280 - P302 + P352 - P308 + P313
• Hazard Classifications: Repr. 2 - Skin Sens. 1 - STOT RE 2
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable