SML4434

SC912

≥98% (HPLC)

• Synonym(e): 3,5-dichloro-N-(2-(3-(3-cyanophenyl)ureido)-5-(trifluoromethyl)phenyl)benzamide
• Empirische Formel (Hill-System): C₂₂H₁₃Cl₂F₃N₄O₂
• Molekulargewicht: 493.27
• UNSPSC Code: 12352200
• eCl@ss: 32160703
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

SC912 is a cell penetrant, potent and selective pan- androgen receptor (AR) inhibitor that binds to full-length AR as well as AR-V7 through AR N-terminal domain (IC50 = 0.36 and 1.01 μM, AR-V7 and ARv567es respectively). SC912 disturbs AR-V7 transcriptional activity and impairs AR-V7 nuclear localization and DNA binding. SC912 potently inhibits proliferation, induced cell-cycle arrest, and apoptosis of AR-V7 positive castration-resistant prostate cancer (CRPC) cells. It also inhibits growth of AR-V7 expressing CRPC xenografts.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H317
• Sicherheitshinweise: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1B
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable