SML4465

L-Homopropargylglycine hydrochloride

≥98% (HPLC)

• Synonym(e): (2S)-2-Aminohex-5-ynoic acid hydrochloride, HCl, HPG
• Empirische Formel (Hill-System): C₆H₉NO₂
• CAS-Nummer: 98891-36-2
• Molekulargewicht: 127.14
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

L-Homopropargylglycine (HPG) is a cell-permeable, non-canonical amino acid and structural analog of L-methionine, possessing a terminal alkyne (–C≡CH) group as a bioorthogonal handle. This structure is recognized by the native, wild-type methionyl-tRNA synthetase (MetRS), which mediates its incorporation into nascent polypeptide chains at methionine positions during ribosomal synthesis. Because MetRS promiscuously charges HPG onto tRNAᴹᵉᵗ in most cell types, this results in broad, non-specific labeling of the translatome. The incorporated alkyne handle serves as a versatile platform for covalent ligation via click chemistry, enabling either fluorescent visualization (FUNCAT) or affinity enrichment (BONCAT) of newly synthesized proteins. While lacking cell-type specificity, HPG provides an accessible and powerful tool for monitoring global proteome dynamics.

Disclaimer

Hygroscopic, Store with desiccant

Sicherheitshinweise

• Piktogramme: GHS02
• Signalwort: Danger
• Gefahrencodes: H242
• Sicherheitshinweise: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Lagerklasse: 5.2 - Organic peroxides and self-reacting hazardous materials
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable