SML4482

AF64394

≥97% (HPLC)

• Synonym(e): N-[[4-Chloro-2-(1-methylethoxy)phenyl]methyl]-5-phenyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
• Empirische Formel (Hill-System): C₂₁H₂₀ClN₅O
• CAS-Nummer: 1637300-25-4
• Molekulargewicht: 393.87
• UNSPSC Code: 12352200
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥97% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

AF64394 is a potent and selective inverse agonist for the G protein-coupled receptor GPR3 (IC50 = 0.5 µM GPR3, 7.9 µM GPR6 and 12 µM GPR12) that potently inhibits cAMP accumulation in HEK293 cells. It appears that AF64394 binds to the transmembrane dimer interface and functions as a negative allosteric modulator (NAM) specifically targeting dimeric GPR3.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable