SML4485

Solamargine

≥98% (HPLC)

• Synonym(e): α-Solamargine, (3β,22α,25R)-Spirosol-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside, NSC 407810
• Empirische Formel (Hill-System): C₄₅H₇₃NO₁₅
• CAS-Nummer: 20311-51-7
• Molekulargewicht: 868.06
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Solamargine, a pharmacologically versatile steroidal glycoalkaloid, exhibits potent anticancer activity (IC₅₀ 0.91–20 µM) and reverses multidrug resistance by inhibiting P-glycoprotein. Solamargine’s pleiotropic action is defined by a multi-pronged mechanism that induces apoptosis via extrinsic (TNFR/Fas)/intrinsic (Bcl-2/Bax) pathways while suppressing pro-survival (STAT3, PI3K/Akt) and metastatic signaling, potentially guided by selective RBL receptor uptake. This versatility extends to distinct antiviral and anti-inflammatory roles, exemplified by Solamargine’s ability to inhibit HBV replication through MZF1 protein interaction and suppress skin inflammation via the p38 MAPK pathway.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable