SML4496

HOR1-C59, Or5v1/Olfr110 Gs-Agonist

≥98% (HPLC)

• Synonym(e): (4R,5R)-2,2-Dimethyl-N4,N5-bis(phenylmethyl)-1,3-dioxolane-4,5-dicarboxamide, (4R-trans)-2,2-Dimethyl-N,N′-bis(phenylmethyl)-1,3-dioxolane-4,5-dicarboxamide, HOR1-C59
• Empirische Formel (Hill-System): C₂₁H₂₄N₂O₄
• CAS-Nummer: 189574-20-7
• Molekulargewicht: 368.43
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

HOR1-C59 is a cell-permeable, stable and highly selective full agonist of the ectopic olfactory receptor Or5v1/Olfr110, exhibiting approximately 2-fold greater potency than the endogenous oxylipin 12(S)-HEPE (EC50 ≈ 7.12 nM). Mechanistically, HOR1-C59 selectively drives Gs-protein coupling to trigger the cAMP-PKA cascade in hepatocytes, resulting in the robust phosphorylation (Thr51/Thr53) and nuclear translocation of transcription factor ATF2. Once in the nucleus, ATF2 binds the Cpt1α promoter (-1761 to -2000 bp region) to upregulate the expression of Cpt1α. Through this direct engagement of mitochondrial β-oxidation machinery, HOR1-C59 effectively reverses diet-induced obesity, hepatic steatosis, and insulin resistance in an Olfr110-dependent manner.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• Gefahrencodes: H302
• Sicherheitshinweise: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable