1045520

Azacitidin

United States Pharmacopeia (USP) Reference Standard

• Synonym(e): 5-Azacytidin, 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-on, Ladakamycin
• Empirische Formel (Hill-System): C₈H₁₂N₄O₅
• CAS-Nummer: 320-67-2
• Molekulargewicht: 244.20
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329749084
• MDL number: MFCD00006539
• Beilstein/REAXYS Number: 620461

Eigenschaften

• grade: pharmaceutical primary standard
• agency: USP
• API family: azacitidine
• manufacturer/tradename: USP
• mp: 226-232 °C (dec.) (lit.)
• application(s): pharmaceutical; pharmaceutical (small molecule)
• format: neat
• SMILES string: NC1=NC(=O)N(C=N1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
• InChI: 1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1
• InChI key: NMUSYJAQQFHJEW-KVTDHHQDSA-N
• Gene Information: human ... DNMT1(1786), DNMT3A(1788)

Beschreibung

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Azacitidine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Ein wirksamer Wachstumshemmer und stark zytotoxischer Wirkstoff; hemmt die DNA-Methyltransferase, ein wichtiger Regulationsmechanismus der Genexpression und Genaktivierung und -stilllegung.

Wirksamer Wachstumshemmer und stark zytotoxischer Wirkstoff; hemmt die DNA-Methyltransferase.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07,GHS09
• Signalwort: Danger
• Gefahrencodes: H302,H341,H350,H360FD,H372,H410
• Sicherheitshinweise: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 1A - Muta. 2 - Repr. 1B - STOT RE 1
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Was ist los?: WGK 3