- Synthesis of diverse analogues of Oenostacin and their antibacterial activities.
Synthesis of diverse analogues of Oenostacin and their antibacterial activities.
Bioorganic & medicinal chemistry (2006-10-13)
Vandana Srivastava, Mahendra P Darokar, Atiya Fatima, J K Kumar, Chinmay Chowdhury, Hari Om Saxena, Gaurav R Dwivedi, Kunal Shrivastava, Vivek Gupta, S K Chattopadhyay, Suaib Luqman, M M Gupta, Arvind S Negi, Suman P S Khanuja
PMID17035037
ZUSAMMENFASSUNG
Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC(50) ranging from 0.49 to 0.67 microM as compared to Oenostacin (EC(50)=0.12 microM).
MATERIALIEN