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Merck

Evaluation of the film-forming property of hydrogenated rosin.

Drug development and industrial pharmacy (2003-10-23)
P M Satturwar, S V Fulzele, S B Joshi, A K Dorle
ZUSAMMENFASSUNG

The film-forming and coating properties of a new biomaterial, hydrogenated rosin (HR), is investigated in the present communication. Films produced by casting method are studied for mechanical, (tensile strength, elongation, and Young's modulus), water vapor transmission, and moisture absorption characteristics. Type of plasticizer and its concentration were observed to play an important role in modifying the film characteristics. Dibutyl sebacate (DBS), a hydrophobic plasticizer, was found to be suitable for development of flexible and smooth films. Film formulations plasticized with DBS were investigated for coating the drug layered nonpareil seeds where plasticization facilitated development of smooth and uniformly coated pellets. The increase in coat buildup, however, did not sustain the drug release significantly. The studies conclude that HR films promise utility as moisture-protective hydrophobic, film-coating materials.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung

Sigma-Aldrich
Dibutylsebacat, ≥97.0% (GC)
Sigma-Aldrich
Dibutylsebacat, technical grade
Supelco
Dibutylsebacat, Pharmaceutical Secondary Standard; Certified Reference Material