- One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines.
One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines.
The Journal of organic chemistry (2006-03-25)
Alexey P Ilyn, Marina V Loseva, Vladimir Y Vvedensky, Elena B Putsykina, Sergey E Tkachenko, Dmitri V Kravchenko, Alexandr V Khvat, Mikhail Y Krasavin, Alexandre V Ivachtchenko
PMID16555836
ZUSAMMENFASSUNG
We present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and 5-oxo-1,4-thiazepine-3-carboxamides using a modification of four-component Ugi condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.