- A glutaric acid ester as carrier system for sustained delivery of lamuvidine (3TC) dimers.
A glutaric acid ester as carrier system for sustained delivery of lamuvidine (3TC) dimers.
Nucleosides, nucleotides & nucleic acids (2007-12-07)
H B Lazrek, J J Vasseur, Jack Secrist, Joachim W Engels
PMID18058545
ZUSAMMENFASSUNG
We report the synthesis of homo and heterodimers of 3TC conjugates. All new dimers were screened for their ability to inhibit HIV-1 in MT4 cell line and were compared to AZT alone and showed marked antiviral activity.
MATERIALIEN