Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA.

Screening for reactive metabolites using electro-optical arrays featuring human liver cytosol and microsomal enzyme sources and DNA.

Chemical communications (Cambridge, England) (2009-09-03)

Linlin Zhao, John B Schenkman, James F Rusling

PMID19724793

ZUSAMMENFASSUNG

We demonstrate for the first time the combination of human liver cytosol and microsomal enzyme sources into an electro-optical array to screen for reactive metabolites produced in multi-enzyme metabolic processes.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

D40752

Sigma-Aldrich

1,2-Dibromethan, 98%

240656

Sigma-Aldrich

1,2-Dibromethan, ≥99%

03505

Sigma-Aldrich

1,2-Dibromethan, purum, ≥98.0% (GC)

48880-U

Supelco

1,2-Dibromethan -Lösung, certified reference material, 200 μg/mL in methanol

A55500

Sigma-Aldrich

2-Aminofluoren, 98%