Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid.

Evaluation of microcrystalline cellulose II (MCCII) as an alternative extrusion-spheronization aid.

Die Pharmazie (2012-08-15)

J Rojas, V Kumar

ZUSAMMENFASSUNG

Microcrystalline cellulose II (MCCII) is a different allomorph of MCC that can be used as a filler and a disintegrant for direct compression. MCCII was studied as new pelletization aid with the aim to prepare pellets with a faster drug release than MCCI-based pellets. MCCII-based pellets showed an immediate diphenydramineHCl release profile comparable to that of Benadryl and a faster griseofulvin release than MCCI-based pellets. MCCII offers potential to use as an alternative pelletization aid.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

D3630

Sigma-Aldrich

Diphenhydramin -hydrochlorid, ≥98% (HPLC)

PHR1015

Supelco

Diphenhydramin -hydrochlorid, Pharmaceutical Secondary Standard; Certified Reference Material

G4753

Sigma-Aldrich

Griseofulvin, from Penicillium griseofulvum, 97.0-102.0%

D-015

Supelco

Diphenhydramine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

D2600000

Diphenhydramin -hydrochlorid, European Pharmacopoeia (EP) Reference Standard