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Merck

Surface functionality as a means to impact polymer nanoparticle size and structure.

Langmuir : the ACS journal of surfaces and colloids (2013-02-27)
Julia Schneider, Andrew P Jallouk, Daniela Vasquez, Ralf Thomann, Aurélien Forget, Christopher J Pino, V Prasad Shastri
PMID23438034
ZUSAMMENFASSUNG

When polymeric nanoparticles (NPs) are formed by nanoprecipitation, which is a nucleation-growth process, the control over size requires changing the polymer concentration or solvent composition. Here, we demonstrate that the NP size can be controlled independent of polymer variables by introducing a polyelectrolyte (PE) in the aqueous phase. PEs that exhibit hydrogen bonding (H-bonding) yield a reduction in NP size, whereas PEs that do not possess this characteristic promote the formation of larger NPs. The observed effect can be attributed to the formation of a diffusional barrier around the NP in the form of a dense shell. This principle of controlling NP size is not limited to polymers and can also be employed in the production of lipid NPs.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
440744
Sigma-Aldrich
Polycaprolacton, average Mn 80,000
181285
Sigma-Aldrich
Poly(acrylsäure), average Mv ~450,000
243051
Sigma-Aldrich
Poly(natrium-4-styrolsulfonat), average Mw ~70,000
323667
Sigma-Aldrich
Poly(acrylsäure)
440752
Sigma-Aldrich
Polycaprolacton, average Mw ~14,000, average Mn ~10,000 by GPC
561223
Sigma-Aldrich
Poly(4-styrolsulfonsäure) -Lösung, Mw ~75,000, 18 wt. % in H2O
416002
Sigma-Aldrich
Poly(acrylsäure) -Lösung, average Mw ~250,000, 35 wt. % in H2O
447013
Sigma-Aldrich
Poly(acrylsäure-Natriumsalz), average Mw ~5,100 by GPC, powder
704105
Sigma-Aldrich
Polycaprolacton, average Mn 45,000
523925
Sigma-Aldrich
Poly(acrylsäure) -Lösung, average Mw ~100,000, 35 wt. % in H2O
434574
Sigma-Aldrich
Poly(natrium-4-styrolsulfonat), average Mw ~1,000,000, powder
561967
Sigma-Aldrich
Poly(natrium-4-styrolsulfonat) -Lösung, average Mw ~200,000, 30 wt. % in H2O
306215
Sigma-Aldrich
Poly(acrylsäure), average Mv ~1,250,000
420344
Sigma-Aldrich
Poly(acrylsäure-Natriumsalz), average Mw ~2,100
416029
Sigma-Aldrich
Poly(acrylsäure, Natriumsalz) -Lösung, average Mw ~8,000, 45 wt. % in H2O
535931
Sigma-Aldrich
Poly(acrylsäure) -Lösung, average Mw ~2,000, 50 wt. % in H2O, electronic grade
416010
Sigma-Aldrich
Poly(acrylsäure, Natriumsalz) -Lösung, 45 wt. % in H2O
527483
Sigma-Aldrich
Poly(natrium-4-styrolsulfonat) -Lösung, average Mw ~70,000, 30 wt. % in H2O
306231
Sigma-Aldrich
Poly(acrylsäure), average Mv ~4,000,000
306223
Sigma-Aldrich
Poly(acrylsäure), average Mv ~3,000,000
527491
Sigma-Aldrich
Poly(natrium-4-styrolsulfonat) -Lösung, average Mw ~1,000,000, 25 wt. % in H2O
181293
Supelco
Poly(acrylsäure), analytical standard, average Mn 130,000 (Typical)
81123
Supelco
Poly(acrylsäure-Natriumsalz), analytical standard, suitable for gel permeation chromatography (GPC), 16,000
81117
Supelco
Poly(acrylsäure-Natriumsalz), analytical standard, suitable for gel permeation chromatography (GPC), 1,250