- Monanchomycalin C, a new pentacyclic guanidine alkaloid from the far-eastern marine sponge Monanchora pulchra.
Monanchomycalin C, a new pentacyclic guanidine alkaloid from the far-eastern marine sponge Monanchora pulchra.
Natural product communications (2013-12-21)
Ksenya M Tabakmakher, Vladimir A Denisenko, Alla G Guzii, Pavel S Dmitrenok, Sergey A Dyshlovoy, Hyi-Seung Lee, Tatyana N Makarieva
PMID24354184
ZUSAMMENFASSUNG
A new pentacyclic guanidine alkaloid, monanchomycalin C (1), along with the earlier known ptilomycalin A (2), were isolated from the Far-Eastern marine sponge Monanchora pulchra. The structure of 1 was elucidated using 1D and 2D NMR spectroscopic and ma ss spectrometric da ta. Compounds 1 and 2 exhibited cytotoxic activities against human breast cancer MDA-MB-231 cells with IC50 values of 8.2 microM and 4.3 pM, respectively.
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