Ocular manifestations of monoclonal copper-binding immunoglobulin.

Ocular manifestations of monoclonal copper-binding immunoglobulin.

Survey of ophthalmology (2013-10-12)

Sejal Shah, Edgar M Espana, Curtis E Margo

ZUSAMMENFASSUNG

The dense accumulation of copper in Descemet membrane and lens capsule is the characteristic manifestation of a circulating monoclonal antibody with strong affinity for copper. The overproduction of this monoclonal immunoglobulin may be associated with either multiple myeloma or a benign monoclonal gammopathy. Despite prolonged exposure to elevated serum copper, no other tissues in the body are adversely affected by this redox metal. We describe the clinical and pathological findings in a 46-year-old woman with this disorder.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

266086

Sigma-Aldrich

Kupfer, powder, <425 μm, 99.5% trace metals basis

203122

Sigma-Aldrich

Kupfer, powder, 99.99% trace metals basis

349178

Sigma-Aldrich

Kupfer, foil, thickness 0.25 mm, 99.98% trace metals basis

207780

Sigma-Aldrich

Kupfer, powder, <75 μm, 99%

349216

Sigma-Aldrich

Kupfer, wire, diam. 1.0 mm, ≥99.9%

326453

Sigma-Aldrich

Kupfer, powder (spheroidal), 10-25 μm, 98%

357456

Sigma-Aldrich

Kupfer, powder (dendritic), <45 μm, 99.7% trace metals basis

349208

Sigma-Aldrich

Kupfer, foil, thickness 0.025 mm, 99.98% trace metals basis

774103

Sigma-Aldrich

Kupfer, nanopowder, 60-80 nm particle size (APS), ≥99.5% trace metals basis

61139

Sigma-Aldrich

Kupfer, turnings, purum p.a., ≥99.0%

311405

Sigma-Aldrich

Kupfer, ACS reagent, granular, 10-40 mesh, ≥99.90%

12816

Sigma-Aldrich

Kupfer, foil, ≥99.8% (complexometric)

254177

Sigma-Aldrich

Kupfer, beads, 2-8 mm, 99.9995% trace metals basis

266744

Sigma-Aldrich

Kupfer, foil, thickness 1.0 mm, 99.999% trace metals basis

GF66556491

Kupfer, mesh, 100x100mm, nominal aperture 0.14mm, thickness 0.25mm, wire diameter 0.115mm, 100x100 wires/inch, open area 30.3%, plain weave mesh

349151

Sigma-Aldrich

Kupfer, foil, thickness 0.5 mm, 99.98% trace metals basis

326429

Sigma-Aldrich

Kupfer, wire, diam. 0.25 mm, 99.999% trace metals basis

223409

Sigma-Aldrich

Kupfer, shot, −3-+14 mesh, 99%

326488

Sigma-Aldrich

Kupfer, beads, 2-8 mm, ≥99.99% trace metals basis

GF86528155

Kupfer, wire reel, 100m, diameter 0.05mm, annealed, 99.9%

349224

Sigma-Aldrich

Kupfer, wire, diam. 2.0 mm, 99.999% trace metals basis

326410

Sigma-Aldrich

Kupfer, wire, diam. 0.64 mm, 99.995% trace metals basis

GF90165023

Kupfer, sheet, 100x100mm, thickness 6.35mm, 99.95+%

GF37929134

Kupfer, rod, 500mm, diameter 2.0mm, as drawn, 99.99+%

GF50190027

Kupfer, rod, 1000mm, diameter 4.8mm, hard, 99.9%

GF00920898

Kupfer, rod, 100mm, diameter 9.5mm, hard, 99.9%

GF16694006

Kupfer, rod, 50mm, diameter 6.35mm, as drawn, 99.999%

GF14145689

Kupfer, mesh, 600x600mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF95621812

Kupfer, foil, 100x100mm, thickness 0.1mm, hard, 99.95+%

GF20661083

Kupfer, tube, 1000mm, outside diameter 12.7mm, inside diameter 10.26mm, wall thickness 1.22mm, as drawn, 99.9%