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  • Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

Anticancer research (2015-01-01)
Maurizio Pompili, Nicoletta De Matthaeis, Antonio Saviano, Ilario De Sio, Giampiero Francica, Franco Brunello, Alessandro Cantamessa, Antonio Giorgio, Umberto Scognamiglio, Fabio Fornari, Francesco Giangregorio, Fabio Piscaglia, Silvia Gualandi, Eugenio Caturelli, Paola Roselli, Laura Riccardi, Gian Ludovico Rapaccini
PMID25550567
ZUSAMMENFASSUNG

The impact of radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) on survival in patients with small hepatocellular carcinoma (HCC) is unclear. We compared their efficacy in cirrhotics with single HCC ≤2 cm. Two hundred forty-four cirrhotics with single HCC ≤2 cm treated with PEI (108 cases) or RFA (136 cases) were enrolled in the study. Eighty-one patients in each group were selected for propensity score matching analysis. The five-year survival was not significantly different (64.7% in PEI and 72.9% in RFA group) but the 5-year recurrence (73.3% in PEI and 49% in RFA group, p=0.023) and local tumor progression (49% in PEI and 30.1% in RFA group, p=0.018) were higher in the PEI group. PEI and RFA are equally effective in treating HCCs smaller than 2 cm in terms of 5-year survival, despite higher cumulative and local recurrence rates, in patients treated with PEI.

MATERIALIEN
Produktnummer
Marke
Produktbeschreibung
E7023
Sigma-Aldrich
Ethyl alcohol, Pure 200 proof, Molecular Biology
459844
Sigma-Aldrich
Ethyl alcohol, Pure, 200 proof, ACS reagent, ≥99.5%
493546
Sigma-Aldrich
Ethyl alcohol, Pure, 200 proof, meets USP testing specifications
459836
Sigma-Aldrich
Ethyl alcohol, Pure, 200 proof, anhydrous, ≥99.5%
E7148
Sigma-Aldrich
Ethyl alcohol, Pure 190 proof, for molecular biology
493511
Sigma-Aldrich
Ethyl alcohol, Pure, 190 proof, ACS spectrophotometric grade, 95.0%
51976
Sigma-Aldrich
Ethanol, BioUltra, Molecular Biology, ≥99.8%, (absolute alcohol, without additive, A15 o1)
PHR1070
Supelco
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02483
Supelco
Ethanol, standard for GC
02857
Sigma-Aldrich
Ethanol, purum, fine spirit, denaturated with 4.8% methanol, F25 METHYL1, ~96% (based on denaturant-free substance)
E-029
Supelco
Ethanol-50, 50 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
E-033
Supelco
Ethanol-300, 300 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
277649
Sigma-Aldrich
Reagent Alcohol, anhydrous, ≤0.003% water
E-040
Supelco
Ethanol-10, 10 mg/dL in H2O, pack of 10 × 1.2 mL ampules, certified reference material, Cerilliant®
E-030
Supelco
Ethanol-80, 80 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
E-031
Supelco
Ethanol-100 (10 Ampullen/Kit), 100 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
02851
Sigma-Aldrich
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676829
Sigma-Aldrich
Reagent Alcohol, anhydrous, ≤0.005% water
48075
Supelco
Ethanol -Lösung, certified reference material, 2000 μg/mL in methanol
29221
Sigma-Aldrich
Ethanol, tested according to Ph. Eur.
E-053
Supelco
Ethanol-500, 500 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
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Supelco
Ethanol-150, 150 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
E-032
Supelco
Ethanol-200 (10 Ampullen/Kit), 200 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
1012772
USP
Dehydrated Alcohol, United States Pharmacopeia (USP) Reference Standard
E-036
Supelco
Ethanol -Lösung, 400 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
E-034
Supelco
Ethanol Calibration Kit, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
E-035
Supelco
Ethanol -Lösung, 25 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
E-056
Supelco
Ethanol-20 (10 Ampullen/Kit), 20 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®
E-045
Supelco
Ethanol -Lösung, 40 mg/dL in H2O, ampule of 10 × 1.2 mL, certified reference material, Cerilliant®