Molecular imprinted magnetic nanoparticles for controlled delivery of mitomycin C.

Molecular imprinted magnetic nanoparticles for controlled delivery of mitomycin C.

Artificial cells, nanomedicine, and biotechnology (2013-08-14)

Deniz Türkmen, Nilay Bereli, M Emin Çorman, Huma Shaikh, Sinan Akgöl, Adil Denizli

ZUSAMMENFASSUNG

Controlled drug delivery system is a technique which has considerable recent potential in the fields of pharmacy and medicine. Mitomycin C is commonly used drug in the treatment of superficial bladder and breast cancers. In the present study, mitomycin C-imprinted magnetic poly(hydroxyethyl methacrylate)-based nanoparticles (MIMNs) were prepared using surfactant free emulsion polymerization for controlled delivery of mitomycin C. The MIMNs were characterized by fourier transform infrared spectroscopy, scanning electron microscopy, atomic force microscopy, electron spin resonance, and elemental analysis. The average particle diameter of MIMNs was about 200 nm.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

216224

Sigma-Aldrich

Kaliumpersulfat, ACS reagent, ≥99.0%

477028

Sigma-Aldrich

2-Hydroxyethylmethacrylat, ≥99%, contains ≤50 ppm monomethyl ether hydroquinone as inhibitor

335681

Sigma-Aldrich

Ethylenglykoldimethacrylat, 98%, contains 90-110 ppm monomethyl ether hydroquinone as inhibitor

60489

Sigma-Aldrich

Kaliumperoxodisulfat, puriss. p.a., ACS reagent, ≥99.0% (RT)

128635

Sigma-Aldrich

2-Hydroxyethylmethacrylat, contains ≤250 ppm monomethyl ether hydroquinone as inhibitor, 97%

637106

Sigma-Aldrich

Eisen(II,III)-oxid, nanopowder, 50-100 nm particle size (SEM), 97% trace metals basis

310069

Sigma-Aldrich

Eisen(II,III)-oxid, powder, <5 μm, 95%

379824

Sigma-Aldrich

Kaliumpersulfat, 99.99% trace metals basis

518158

Sigma-Aldrich

Eisen(II,III)-oxid, 99.99% trace metals basis

700312

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size, 5 mg/mL in toluene

747408

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 30 nm avg. part. size (TEM), PEG functionalized, dispersion, 1 mg/mL Fe in H₂O

725358

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size, 5 mg/mL in H₂O

725331

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 5 nm avg. part. size, 5 mg/mL in H₂O

747254

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size (TEM), carboxylic acid functionalized, 5 mg/mL Fe in H₂O, dispersion

725366

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 20 nm avg. part. size, 5 mg/mL in H₂O

747327

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 30 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion

17348

Sigma-Aldrich

2-Hydroxyethylmethacrylat

700320

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 5 nm avg. part. size, 5 mg/mL in toluene

700304

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 20 nm avg. part. size, 5 mg/mL in toluene

747319

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion

747300

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion

790508

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 5 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion