5-Fluorouracil intercalated iron oxide@layered double hydroxide core-shell nano-composites with isotropic and anisotropic architectures for shape-selective drug delivery applications.

5-Fluorouracil intercalated iron oxide@layered double hydroxide core-shell nano-composites with isotropic and anisotropic architectures for shape-selective drug delivery applications.

Materials science & engineering. C, Materials for biological applications (2015-06-29)

Gülsevde Tuncelli, Ahmet Nedim Ay, Birgül Zümreoglu-Karan

ZUSAMMENFASSUNG

We report the synthesis, characterization and in vitro release behavior of anti-cancer drug carrying iron oxide@layered double hydroxide core-shell nanocomposites with sizes ranging from 40 to 300 nm, good drug loading capacities and soft ferromagnetic properties. HRTEM analyses verified that nearly spherical isotropic carriers were obtained by coating spherical magnetite particles while anisotropic carriers were obtained by coating spindle-shaped hematite particles. They both displayed a fluctuating in vitro release profile with a higher release percentage for the anisotropic carrier.

MATERIALIEN

Produktnummer

Marke

Produktbeschreibung

F6627

Sigma-Aldrich

5-Fluorouracil, ≥99% (HPLC), powder

637106

Sigma-Aldrich

Eisen(II,III)-oxid, nanopowder, 50-100 nm particle size (SEM), 97% trace metals basis

310069

Sigma-Aldrich

Eisen(II,III)-oxid, powder, <5 μm, 95%

518158

Sigma-Aldrich

Eisen(II,III)-oxid, 99.99% trace metals basis

700312

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size, 5 mg/mL in toluene

747408

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 30 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion

725358

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size, 5 mg/mL in H₂O

725331

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 5 nm avg. part. size, 5 mg/mL in H₂O

747254

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size (TEM), carboxylic acid functionalized, 5 mg/mL Fe in H₂O, dispersion

725366

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 20 nm avg. part. size, 5 mg/mL in H₂O

747327

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 30 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion

700320

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 5 nm avg. part. size, 5 mg/mL in toluene

700304

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 20 nm avg. part. size, 5 mg/mL in toluene

747319

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion

747300

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 10 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion

F8423

Sigma-Aldrich

Fluorouracil, meets USP testing specifications

790508

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 5 nm avg. part. size (TEM), PEG functionalized, 1 mg/mL Fe in H₂O, dispersion

747343

Sigma-Aldrich

Eisenoxid(II,III), magnetische Nanopartikel -Lösung, 5 nm avg. part. size (TEM), amine functionalized, 1 mg/mL Fe in H₂O, dispersion