- Designing of peptide substrates. Different approaches exemplified by new chromogenic substrates for kallikreins and urokinase.
Designing of peptide substrates. Different approaches exemplified by new chromogenic substrates for kallikreins and urokinase.
Haemostasis (1978-01-01)
G Claeson, L Aurell, P Friberger, S Gustavsson, G Karlsson
PMID658780
ZUSAMMENFASSUNG
Chromogenic peptide substrates for serine proteases have been designed by using two approaches: (1) by using the natural substrate as a model and (2) by structure-activity correlations obtained through screening of a large number of tripeptides. Some recent examples, substrates for kallikreins and urokinase are given.
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