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Merck

33226

Glycine

99.7-101% (calc. to the dried substance), crystalline powder, suitable for IR spectroscopy, puriss. p.a., reag. Ph. Eur., buffer substance

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:
NH2CH2COOH
CAS Number:
56-40-6
Molecular Weight:
75.07
NACRES:
NA.21
PubChem Substance ID:
57648780
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-272-2
MDL number:
MFCD00008131
Beilstein/REAXYS Number:
635782

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Product Name

Glycine, puriss. p.a., reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

SMILES string

NCC(O)=O

agency

USP/NF
reag. Ph. Eur.

grade

puriss. p.a.

assay

99.7-101% (calc. to the dried substance)

form

crystalline powder

technique(s)

IR spectroscopy: suitable

impurities

≤0.001% heavy metals (as Pb)
≤0.02% ammonium (NH4)
≤0.1% water (Karl Fischer)
≤1.0% ninhydrin-positive substances

ign. residue

≤0.05% (as SO4)

loss

≤0.5% loss on drying, 105°C, 2 h

pH

5.9-6.4 (20 °C, 5%)

pKa (25 °C)

(1) 2.35, (2) 9.60
2.35

mp

240 °C (dec.) (lit.)

anion traces

chloride (Cl-): ≤30 mg/kg
sulfate (SO42-): ≤20 mg/kg

cation traces

Fe: ≤5 mg/kg

suitability

in accordance for identity (IR)

functional group

amine
carboxylic acid

Quality Level

200

Gene Information

rat ... Grin2a(24409)

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This Item
1.036691.041691.00590
Glycine puriss. p.a., reag. Ph. Eur., buffer substance, 99.7-101% (calc. to the dried substance)

Sigma-Aldrich

33226

Glycine

Glycine granulated, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

SAFC

1.03669

Glycine

Glycine buffer substance for electrophoresis

Sigma-Aldrich

1.04169

Glycine

Glycine crystalline, EMPROVE® EXPERT, Ph. Eur., BP, ChP, JP, USP

SAFC

1.00590

Glycine

form

crystalline powder

form

granular

form

solid

form

crystalline, solid

grade

puriss. p.a.

grade

-

grade

-

grade

-

assay

99.7-101% (calc. to the dried substance)

assay

99.0-101.0% (calculated on dried substance, perchloric acid titration)

assay

≥99.7% (perchloric acid titration)

assay

98.5-101.0% (calculated on dried substance, perchloric acid titration)

technique(s)

IR spectroscopy: suitable

technique(s)

inhibition assay: suitable

technique(s)

electrophoresis: suitable

technique(s)

inhibition assay: suitable

functional group

amine, carboxylic acid

functional group

-

functional group

-

functional group

-

impurities

≤0.001% heavy metals (as Pb), ≤0.1% water (Karl Fischer), ≤0.02% ammonium (NH4), ≤1.0% ninhydrin-positive substances

impurities

-

impurities

-

impurities

-

Application

Glycine can be used as:
  • A reactant in the natural soil clay-catalyzed cleavage and polycondensation with pyrogallol.
  • A catalyst in the Knoevenagel reaction between aryl aldehydes and malononitrile to form a C=C bond.
  • A reagent in the metal-free synthesis of biaryls from aryl sulfoxides and sulfonanilides via sigmatropic rearrangement.

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB6099
SDBB4466
SDBB2364
SDBB2230
STBL3196

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Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
Richard A Felix et al.
Brain structure & function, 220(5), 2639-2652 (2014-06-30)
The mammalian superior paraolivary nucleus (SPON) is a major source of GABAergic inhibition to neurons in the inferior colliculus (IC), a well-studied midbrain nucleus that is the site of convergence and integration for the majority ascending auditory pathways en route
Zoé Husson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9418-9431 (2014-07-11)
The principal neurons of the cerebellar nuclei (CN), the sole output of the olivo-cerebellar system, receive a massive inhibitory input from Purkinje cells (PCs) of the cerebellar cortex. Morphological evidence suggests that CN principal cells are also contacted by inhibitory
Li-Chun Tu et al.
The EMBO journal, 32(24), 3220-3230 (2013-11-12)
Nuclear pore complexes (NPCs) mediate cargo traffic between the nucleus and the cytoplasm of eukaryotic cells. Nuclear transport receptors (NTRs) carry cargos through NPCs by transiently binding to phenylalanine-glycine (FG) repeats on intrinsically disordered polypeptides decorating the NPCs. Major impediments
Suzanne L Grant et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 844(2), 278-282 (2006-08-08)
A simple and versatile methodology using high-performance liquid chromatography (HPLC) with fluorimetric detection was developed to simultaneously determine d-serine along with other metabolically related neuroactive amino acids in the glutamatergic system: L-serine, L-glutamate, L-glutamine, and glycine. On-column sensitivity was in
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