L-Serine

Name: <SC>L</SC>-Serine
Brand: SIAL

certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Synonym(s):

(S)-2-Amino-3-hydroxypropionic acid

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About This Item

Linear Formula:

HOCH₂CH(NH₂)CO₂H

CAS Number:

56-45-1

Molecular Weight:

105.09

NACRES:

NA.24

PubChem Substance ID:

329758055

eCl@ss:

32160406

UNSPSC Code:

41116107

EC Number:

200-274-3

MDL number:

MFCD00064224

Beilstein/REAXYS Number:

1721404

Key Documents

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Product Name

L-Serine, certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

SMILES string

N[C@@H](CO)C(O)=O

InChI

1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1

InChI key

MTCFGRXMJLQNBG-REOHCLBHSA-N

grade

certified reference material
TraceCERT^®

product line

TraceCERT^®

analyte chemical class(es)

amino acids, peptides, proteins

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

mp

222 °C (dec.) (lit.)

application(s)

food and beverages

format

neat

Quality Level

300

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Amino Acid, Peptide & Protein Standards

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Show Differences

1 of 4

This Item	1612506	PHR1103	S4311
Supelco 54763 L-Serine	USP 1612506 L-Serine	Supelco PHR1103 L-Serine	Sigma-Aldrich S4311 L-Serine
application(s) food and beverages	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) -	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) cell culture \| mammalian: suitable
format neat	format neat	format neat	format -
Quality Level 300	Quality Level -	Quality Level 300	Quality Level 300
grade certified reference material, TraceCERT^®	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade -
manufacturer/tradename Manufactured by: Sigma-Aldrich Production GmbH, Switzerland	manufacturer/tradename USP	manufacturer/tradename -	manufacturer/tradename -

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Precursor of glycine by serine hydroxymethyltransferase.

General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

Check out the entire portfolio of our amino acids certified reference materials (CRM)

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Reduced D-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients.

Kenji Hashimoto et al.

Progress in neuro-psychopharmacology & biological psychiatry, 29(5), 767-769 (2005-06-09)

Several lines of evidence suggest that D-serine, an endogenous agonist of the glycine site on the NMDA receptors, might play a role in the pathophysiology of schizophrenia. The purpose of this study was to determine whether levels of D- and

A peptide hormone and its receptor protein kinase regulate plant cell expansion.

Miyoshi Haruta et al.

Science (New York, N.Y.), 343(6169), 408-411 (2014-01-25)

Plant cells are immobile; thus, plant growth and development depend on cell expansion rather than cell migration. The molecular mechanism by which the plasma membrane initiates changes in the cell expansion rate remains elusive. We found that a secreted peptide

Genome conformation capture reveals that the Escherichia coli chromosome is organized by replication and transcription.

Cedric Cagliero et al.

Nucleic acids research, 41(12), 6058-6071 (2013-05-02)

To fit within the confines of the cell, bacterial chromosomes are highly condensed into a structure called the nucleoid. Despite the high degree of compaction in the nucleoid, the genome remains accessible to essential biological processes, such as replication and

Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation.

Hisaaki Shinohara et al.

Science (New York, N.Y.), 344(6185), 760-764 (2014-05-17)

A switchlike response in nuclear factor-κB (NF-κB) activity implies the existence of a threshold in the NF-κB signaling module. We show that the CARD-containing MAGUK protein 1 (CARMA1, also called CARD11)-TAK1 (MAP3K7)-inhibitor of NF-κB (IκB) kinase-β (IKKβ) module is a

L-serine in disease and development.

Tom J de Koning et al.

The Biochemical journal, 371(Pt 3), 653-661 (2003-01-22)

The amino acid L-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation. L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long

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