This product is not tested for inducing an animal model of androgenic alopecia. Determination of suitability must be conducted experimentally.
A8380
5α-Androstan-17β-ol-3-one
synthetic, ≥97.5%, Androgen hormone, powder
Synonym(s):
17β-Hydroxy-5α-androstan-3-one, 4,5α-Dihydrotestosterone, Androstanolone, Stanolone
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About This Item
Empirical Formula (Hill Notation):
C19H30O2
CAS Number:
Molecular Weight:
290.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
208-307-3
MDL number:
Beilstein/REAXYS Number:
2056371
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Product Name
5α-Androstan-17β-ol-3-one, ≥97.5%
InChI key
NVKAWKQGWWIWPM-ABEVXSGRSA-N
InChI
1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
SMILES string
[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CCC(=O)C2
biological source
synthetic
sterility
non-sterile
assay
≥97.5%
form
powder
drug control
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
ethanol: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
Quality Level
Gene Information
human ... AR(367), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462)
mouse ... Esr1(13982)
rat ... Ar(24208), Esr1(24890), Nr3c1(24413), Nr3c2(25672), Pgr(25154)
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Related Categories
1 of 4
This Item | 10300 | A7755 | H2898 |
|---|---|---|---|
| assay ≥97.5% | assay ≥99.0% (TLC) | assay ≥98% (TLC) | assay ≥97% (HPLC) |
| form powder | form powder | form powder | form powder |
| drug control USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| solubility ethanol: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow | solubility - | solubility methanol: 19.60-20.40 mg/mL, clear, colorless | solubility methanol: 50 mg/mL, clear, colorless |
| biological source synthetic | biological source synthetic | biological source - | biological source - |
Application
5α-Androstan-17β-ol-3-one, also referred to as androstanolone or dihydrotestosterone, is an anabolic steroid. Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone, including the development of the male phenotype during embryogenesis and at puberty.
Biochem/physiol Actions
Androstanolone is an anabolic steroid. Testosterone secreted by the testis is converted to dihydrotestosterone in the target tissues where it appears to mediate many of the biological actions of testosterone. Androgens direct the development of the male phenotype during embryogenesis and at puberty.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1A
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Anthony Schroeder et al.
General and comparative endocrinology, 281, 7-16 (2019-05-07)
Sex steroids are involved in sex determination in almost all vertebrates, including species with temperature-dependent sex determination (TSD). It is well established that aromatase and estrogens are involved in ovary determination in TSD species. In contrast, the role of non-aromatizable
Bu B Yeap et al.
The Journal of clinical endocrinology and metabolism, 99(1), E9-18 (2013-11-22)
Testosterone (T) levels decline with age and lower T has been associated with increased mortality in aging men. However, the associations of its metabolites, dihydrotestosterone (DHT) and estradiol (E2), with mortality are poorly defined. We assessed associations of T, DHT
Isabelle Brunet et al.
The Journal of clinical investigation, 124(7), 3230-3240 (2014-06-18)
Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue
Katharine Trenholme et al.
Antimicrobial agents and chemotherapy, 58(7), 3666-3678 (2014-04-16)
Therapies to prevent transmission of malaria parasites to the mosquito vector are a vital part of the global malaria elimination agenda. Primaquine is currently the only drug with such activity; however, its use is limited by side effects. The development
Ken Ye et al.
PloS one, 9(6), e99410-e99410 (2014-06-12)
Infrapatellar fat pad adipose stem cells (IPFP-ASCs) have been shown to harbor chondrogenic potential. When combined with 3D polymeric structures, the stem cells provide a source of stem cells to engineer 3D tissues for cartilage repair. In this study, we
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Is this product suitable for inducing an animal model of androgenic alopecia?
1 answer-
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Is it suitable to treat this in cell culture? I've already seen such recommendations.. However, the fact that it is not sterilized is a bit concerning. would it still be possible?
1 answer-
This product has not been tested for suitability in cell culture. While the powder is not sterile, prepared stock solutions may be filter sterilized. The material is soluble at 50 mg/mL in ethanol and may be further diluted using buffer or medium. The peer-reviewed papers listed on this page reference publications the have listed this product used in a number of applications successfully. There are several in vitro and in vivo applications cited. Please see the link below to review one example publication:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099410Helpful?
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