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Merck

61360

Lactulose

≥98.0% (HPLC)

Synonym(s):

4-O-β-D-Galactopyranosyl-D-fructofuranose, 4-O-β-D-Galactopyranosyl-D-fructose

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About This Item

Empirical Formula (Hill Notation):
C12H22O11
CAS Number:
4618-18-2
Molecular Weight:
342.30
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
57651848
EC Number:
225-027-7
Beilstein/REAXYS Number:
93773
MDL number:
MFCD00151469

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Product Name

Lactulose, ≥98.0% (HPLC)

InChI key

JCQLYHFGKNRPGE-WJONTELPSA-N

InChI

1S/C12H22O11/c13-1-4-6(16)7(17)8(18)11(21-4)22-9-5(2-14)23-12(20,3-15)10(9)19/h4-11,13-20H,1-3H2/t4-,5-,6+,7+,8-,9-,10+,11+,12+/m1/s1

SMILES string

OC[C@H]1O[C@@H](O[C@@H]2[C@@H](CO)O[C@@](O)(CO)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

assay

≥98.0% (HPLC)

form

solid

optical activity

[α]20/D −48±2°, 24 hr, c = 1% in H2O

color

white to off-white

mp

169  °C ((336 °F ))

storage temp.

room temp

Quality Level

100

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1 of 4

This Item
1356803Y0001510L7877
Lactulose ≥98.0% (HPLC)

Sigma-Aldrich

61360

Lactulose

Lactulose United States Pharmacopeia (USP) Reference Standard

USP

1356803

Lactulose

Lactulose for peak identification European Pharmacopoeia (EP) Reference Standard

Y0001510

Lactulose for peak identification

Lactulose ≥95% (HPLC)

Sigma-Aldrich

L7877

Lactulose

assay

≥98.0% (HPLC)

assay

-

assay

-

assay

≥95% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

200

form

solid

form

-

form

-

form

powder

storage temp.

room temp

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

mp

169  °C ((336 °F ))

mp

-

mp

-

mp

169  °C ((336 °F ))

color

white to off-white

color

-

color

-

color

white to off-white

Application

Lactulose has been used in the preparation of milk.[1]
Lactulose, a disaccharide composed of fructose and galactose units, is used as an osmolyte that relieves constipation and supports probiotic processes in the intestine and colon. Lactulose helps stabilize blood glucose and insulin levels.

Biochem/physiol Actions

Lactulose helps to decrease the concentration of blood ammonia in the treatment of hepatic encephalopathy. It is also used to treat constipation as an osmotic laxative. This non-absorbable disaccharide is catabolized through the bacterial flora to short chain fatty acids.[2] The enzymes of the mammalian digestive tract do not have the ability to digest lactulose.[3]

General description

Lactulose is a synthetic derivative of lactose. It is made up of one molecule of galactose and one molecule of fructose.[3]

Other Notes

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5302
BCCM6933
BCCM6930
BCCM6932
BCCL4994

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Lactulose enemas in the treatment of hepatic encephalopathy. Do we help or harm?
de Lorenzo-Pinto A, et al.
Revista espa?ola de Enfermedades Digestivas : Organo Oficial de la Sociedad Espa?ola de Patologia Digestiva (2017)
Meiyan Wang et al.
Journal of agricultural and food chemistry, 66(12), 3155-3160 (2018-03-13)
Aging and oxidative-related events are closely associated with the oxidative damages induced by excess reactive oxygen species (ROS). The phytochemicals nobiletin (NBT) and tangeretin (TAN) and their 5-demethylated derivatives 5-demethylnobiletin (5-DN) and 5-demethyltangeretin (5-DT) are the representative polymethoxyflavone (PMF) compounds
Gastrointestinal drugs
Small Animal Clinical Pharmacology, 469-497 (2008)
Use of lactulose as prebiotic and its influence on the growth, acidification profile and viable counts of different probiotics in fermented skim milk
Oliveira R P D S, et al.
International Journal of Food Microbiology, 145(1), 22-27 (2011)
Tara Raftery et al.
United European gastroenterology journal, 3(3), 294-302 (2015-07-03)
Vitamin D (vitD) supplementation may prolong remission in Crohn's disease (CD); however, the clinical efficacy and mechanisms are unclear. To determine changes in intestinal permeability (IP), antimicrobial peptide (AMP) concentrations and disease markers in CD, in response to vitD supplementation.
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