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Merck

159425

9-Chloroacridine

97%

Synonym(s):

9-Chloroacridine

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About This Item

Empirical Formula (Hill Notation):
C13H8ClN
CAS Number:
1207-69-8
Molecular Weight:
213.66
NACRES:
NA.22
PubChem Substance ID:
24849815
UNSPSC Code:
12352100
EC Number:
214-895-2
MDL number:
MFCD00022266

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Product Name

9-Chloroacridine, 97%

InChI key

BPXINCHFOLVVSG-UHFFFAOYSA-N

InChI

1S/C13H8ClN/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8H

SMILES string

Clc1c2ccccc2nc3ccccc13

assay

97%

form

solid

mp

116-120 °C (lit.)

functional group

chloro

Quality Level

100

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1 of 4

This Item
725188536008714623
9-Chloroacridine 97%

Sigma-Aldrich

159425

9-Chloroacridine

2-Bromo-3-chloropyridine 97%

Sigma-Aldrich

725188

2-Bromo-3-chloropyridine

5-(Aminomethyl)-2-chloropyridine 97%

Sigma-Aldrich

536008

5-(Aminomethyl)-2-chloropyridine

2,3-Diamino-5-chloropyridine 97%

Sigma-Aldrich

714623

2,3-Diamino-5-chloropyridine

assay

97%

assay

97%

assay

97%

assay

97%

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

solid

form

powder

form

solid

form

solid

mp

116-120 °C (lit.)

mp

58-63 °C

mp

28-34 °C

mp

170-175 °C

functional group

chloro

functional group

bromo, chloro

functional group

amine, chloro

functional group

chloro

Application

9-Chloroacridine was employed as chromogenic reagent in the spectrophotometric method for the quantitative determination of dapsone.[1] It was also used in the synthesis of:
  • series of novel chalcones bearing acridine moiety attached to the amino group in their ring A[2]
  • new acridine derivatives[3]
  • 9-phenoxyacridine and 4-phenoxyfuro[2,3-b]quinoline derivatives[4]

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCV5471
MKCQ5872
MKCK4344
MKBW2948V
MKBK2815V

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Paula Bosch et al.
Materials (Basel, Switzerland), 12(18) (2019-09-22)
A second-generation poly(propylene imine) dendrimer modified with acridine and its Cu(II) complex have been synthesized for the first time. It has been found that two copper ions form complexes with the nitrogen atoms of the dendrimeric core by coordinate bonds.
V Tomar et al.
European journal of medicinal chemistry, 45(2), 745-751 (2009-12-22)
A series of novel chalcones bearing acridine moiety attached to the amino group in their ring A have been synthesized through noncatalyzed nucleophilic aromatic substitution reaction between various 3'-aminochalcone or 4'-aminochalcones and 9-chloroacridine. The synthesized chalcone derivatives have been characterized
Yeh-Long Chen et al.
Bioorganic & medicinal chemistry, 11(18), 3921-3927 (2003-08-21)
Mast cells, neutrophils and macrophages are important inflammatory cells that have been implicated in the pathogenesis of acute and chronic inflammatory diseases. To explore a novel anti-inflammatory agent, we have synthesized certain 9-phenoxyacridine and 4-phenoxyfuro[2,3-b]quinoline derivatives and evaluated their anti-inflammatory
Jelena Rupar et al.
Bioelectrochemistry (Amsterdam, Netherlands), 135, 107579-107579 (2020-06-14)
The electrochemical behavior of 9-chloroacridine (9Cl-A), a precursor molecule for synthesis of acridine derivatives with cytostatic activity, is a complex, pH-dependent, diffusion-controlled irreversible process. Oxidation of 9Cl-A initiates with the formation of a cation radical monomer, continues via the formation
Arumugasamy Elangovan et al.
Organic & biomolecular chemistry, 2(21), 3113-3118 (2004-10-27)
Electrogenerated chemiluminescence (ECL) of six new ethyne-based acridine derivatives (1-6) has been studied. The new acridine derivatives were synthesized by cross-coupling of 9-chloroacridine and corresponding donor-substituted phenylethynes under modified Sonogashira conditions. The donor groups were varied in the order of
View All Related Papers

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