MAB3318

Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4

Name: Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4
Brand: MM
Price: 478 EUR
Availability: InStock

clone 136-13H4, Chemicon^®, from mouse

Synonym(s):

Tissue Inhibitor of Metalloproteinase-3

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100 μG

€478.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Key Documents

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Product Name

Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4, clone 136-13H4, Chemicon^®, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

136-13H4, monoclonal

species reactivity

rabbit, human

manufacturer/tradename

Chemicon^®

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_000362.4

UniProt accession no.

P35625

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TIMP3(7078)

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This Item	AB6000	MAB3301	MAB13429
Sigma-Aldrich MAB3318 Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4	Sigma-Aldrich AB6000 Anti-TIMP-3 Antibody, CT	Sigma-Aldrich MAB3301 Anti-TIMP-1 Antibody, clone 147-6D11	Sigma-Aldrich MAB13429 Anti-TIMP-1 Antibody, clone 102D1
Gene Information human ... TIMP3(7078)	Gene Information human ... TIMP3(7078)	Gene Information human ... TIMP1(7076)	Gene Information human ... TIMP1(7076)
biological source mouse	biological source rabbit	biological source mouse	biological source mouse
species reactivity rabbit, human	species reactivity horse, human, rat	species reactivity human	species reactivity human
clone 136-13H4, monoclonal	clone polyclonal	clone 147-6D11, monoclonal	clone 102D1, monoclonal
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified antibody	antibody form purified antibody
UniProt accession no. P35625	UniProt accession no. P35625	UniProt accession no. P01033	UniProt accession no. P01033

Analysis Note

Control
Breast carcinoma tissue

Application

Anti-TIMP-3 Antibody, a.a. 170-188, clone 136-13H4 is an antibody against TIMP-3 for use in IH(P) & WB.

Immunoblotting: 2 ug/mL

Immunohistochemistry (Paraffin):10ug/mL

Immunohistochemistry (Frozen): 2 ug/mL

Research Category
Cell Structure

Research Sub Category
MMPs & TIMPs

Biochem/physiol Actions

Specifically reacts with human TIMP-3. This is a purified mouse monoclonal antibody to an oligopeptide of SWYRGWAPPDKSIINATDP (residue 170-188) on human tissue inhibitor of metalloproteinases-3 (human TIMP-3).
MAB3318 cross-reacts with rabbit TIMP-3, but does not react with human TIMP-1 and human TIMP-2.

Disclaimer

Manufactured by Daiichi Fine Chemical Co., Ltd

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

26 kDa

Immunogen

Epitope: a.a. 170-188

Oligopeptide of SWYRGWAPPDKSIINATDP (residue 170-188) on human tissue inhibitor of metalloproteinases-3.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine Serum albumin.

Protein A purified

Preparation Note

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Promoter hypermethylation contributes to TIMP3 down-regulation in high stage endometrioid endometrial carcinomas.

Lluis Catasus et al.

Histopathology, 62(4), 632-641 (2013-02-06)

Expression of tissue inhibitor of metalloproteinases-3 (TIMP-3) has been found to be decreased in several types of cancer by promoter gene hypermethylation. However, little is known regarding the silencing effect of TIMP3 promoter hypermethylation on gene and protein expression in

Tissue inhibitor of metalloproteinase-3 (TIMP-3) gene is methylated in the development of esophageal adenocarcinoma: loss of expression correlates with poor prognosis.

S Jane Darnton et al.

International journal of cancer, 115(3), 351-358 (2005-02-03)

Amongst involvement in diverse physiological and pathological processes, TIMP-3 may have an important role in tumour development, growth and metastasis by interaction with metalloproteases in the extracellular matrix. We studied the role and prognostic effect of TIMP-3 in esophageal adenocarcinoma

Loss of TIMP3 by promoter methylation of Sp1 binding site promotes oral cancer metastasis.

Chun-Wen Su et al.

Cell death & disease, 10(11), 793-793 (2019-10-19)

The tissue inhibitor of metalloproteinase-3 (TIMP3) is the only member of the TIMP family that binds to the extracellular matrix and suppresses cancer cell growth, angiogenesis, migration, and invasion. However, whether the abnormal expression and promoter methylation of TIMP3 facilitates

Localization and temporal regulation of tissue inhibitors of metalloproteinases 3 and 4 in bovine preovulatory follicles.

Qinglei Li et al.

Reproduction (Cambridge, England), 128(5), 555-564 (2004-10-29)

The matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are potential regulators of the focalized extracellular matrix degradation required for ovulation. The objectives of the present study were to determine localization and temporal regulation of TIMP-3 and TIMP-4 mRNA and

Preexisting high expression of matrix metalloproteinase-2 in tunica media of saphenous vein conduits is associated with unfavorable long-term outcomes after coronary artery bypass grafting.

Bartlomiej Perek et al.

BioMed research international, 2013, 730721-730721 (2013-10-24)

Migration of the smooth muscle cells (SMCs) to the tunica media in the saphenous vein (SV) transplants is facilitated by matrix metalloproteinases (MMPs). The aim of this study was to identify any associations between expression of MMP-2 or endogenous tissue

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