Skip to Content
Merck

B3306

Bisindolylmaleimide IV

≥98% (TLC), solid

Synonym(s):

Ro 31-6233

Slide 1 of 1
Sign In to View Organizational & Contract Pricing.

Select a Size

1 MG

€89.30

€89.30

Please contact Customer Service for Availability
Request a Bulk Order

About This Item

Empirical Formula (Hill Notation):
C20H13N3O2
CAS Number:
119139-23-0
Molecular Weight:
327.34
NACRES:
NA.77
PubChem Substance ID:
24891709
UNSPSC Code:
12352111
MDL number:
MFCD00236432

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Bisindolylmaleimide IV, ≥98% (TLC), solid

InChI

1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)

SMILES string

O=C1NC(=O)C(c2c[nH]c3ccccc23)=C1c4c[nH]c5ccccc45

InChI key

DQYBRTASHMYDJG-UHFFFAOYSA-N

biological source

synthetic (organic)

assay

≥98% (TLC)

form

solid

color

dark red

solubility

DMSO: soluble
methanol: soluble

storage temp.

−20°C

Quality Level

200

Gene Information

human ... CDK2(1017), EGFR(1956)
rat ... Prkca(24680)

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
B4056B3931B3681
Bisindolylmaleimide IV ≥98% (TLC), solid

Sigma-Aldrich

B3306

Bisindolylmaleimide IV

Bisindolylmaleimide XI hydrochloride ≥98% (TLC), solid

Sigma-Aldrich

B4056

Bisindolylmaleimide XI hydrochloride

Bisindolylmaleimide X hydrochloride ≥90%, solid

Sigma-Aldrich

B3931

Bisindolylmaleimide X hydrochloride

Bisindolylmaleimide VII 96% (TLC), solid

Sigma-Aldrich

B3681

Bisindolylmaleimide VII

form

solid

form

solid

form

solid

form

solid

assay

≥98% (TLC)

assay

≥98% (TLC)

assay

≥90%

assay

96% (TLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: soluble, methanol: soluble

solubility

DMSO: soluble

solubility

DMSO: soluble

solubility

DMSO: soluble

color

dark red

color

-

color

-

color

-

Biochem/physiol Actions

Bisindolylmaleimides (BIM) comprises a group of 11 compounds from BIM-I to BIM-XI.[1] BIMs act as an inhibitor of protein kinase C (PKC).[1] They are derived from staurosporine.[2] BIM IX due to its proapoptotic functionality could be useful in targeting tumor proliferation.[3]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000346320
0000346320
SLCQ4940
SLCQ3584
SLCN2754

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Meng-Ling Chen et al.
The journal of pain : official journal of the American Pain Society, 13(10), 945-958 (2012-09-13)
The glial function in morphine tolerance has been explored, but its mechanisms remain unclear. Our previous study has showed that microglia-expressed P2X7 receptors (P2X7R) contribute to the induction of tolerance to morphine analgesia in rats. This study further explored the
Max Hoff et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(7), 2484-2491 (2011-04-12)
Rhythmic activity of cells and cellular networks plays an important role in physiology. In the nervous system oscillations of electrical activity and/or second messenger concentrations are important to synchronize neuronal activity. At the molecular level, rhythmic activity can be initiated
Sibasish Dolai et al.
Proteomics, 11(13), 2683-2692 (2011-06-02)
Basal-like breast cancers are commonly negative for expression of estrogen and progesterone receptors and HER-2 (triple-negative breast cancer), which makes this subtype of breast cancers more aggressive and less responsive to standard treatment. We have applied a small-scale chemical proteomics
Abdullah Mayati et al.
PloS one, 10(12), e0144667-e0144667 (2015-12-15)
Ro 31-8220 is a potent protein kinase C (PKC) inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs). Various PKC-independent effects of Ro 31-8220 have however been demonstrated, including inhibition of the ATP-binding cassette drug transporter breast cancer resistance protein.
Hui He et al.
The Prostate, 70(10), 1119-1126 (2010-03-25)
We have reported that human prostate cancer ARCaP(E) cells undertake epithelial to mesenchymal transition (EMT) when stimulated by certain soluble factors, and that EMT is regulated by surface receptor-elicited signaling pathways through protein phosphorylation. It is known that phorbol ester
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service