This product has not been tested for in vivo use. The material is soluble at 50 mg/mL in 1N HCl. The stock solution would require sterile filtration before further dilution with a sterile buffer or medium.
C6506
4-Chloro-DL-phenylalanine
5-HT synthesis inhibitor, solid
Synonym(s):
PCP, PCPA
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5 G
€86.20
25 G
€302.00
About This Item
Linear Formula:
ClC6H4CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
199.63
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
231-051-9
MDL number:
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Product Name
4-Chloro-DL-phenylalanine,
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChI key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
SMILES string
NC(Cc1ccc(Cl)cc1)C(O)=O
form
solid
greener alternative product score
old score: 2
new score: 1
Find out more about DOZN™ Scoring
greener alternative product characteristics
Less Hazardous Chemical Syntheses
Designing Safer Chemicals
Design for Energy Efficiency
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sustainability
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mp
>240 °C (dec.) (lit.)
greener alternative category
storage temp.
room temp
Quality Level
Gene Information
human ... TPH1(7166), TPH2(121278)
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1 of 4
This Item | P1152 | P6516 | N2132 |
|---|---|---|---|
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| form solid | form powder | form solid | form powder |
| storage temp. room temp | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| Gene Information human ... TPH1(7166), TPH2(121278) | Gene Information - | Gene Information - | Gene Information - |
| greener alternative product score old score: 2 | greener alternative product score old score: 56 | greener alternative product score old score: 51 | greener alternative product score old score: 100 |
| greener alternative product characteristics Less Hazardous Chemical Syntheses | greener alternative product characteristics Designing Safer Chemicals | greener alternative product characteristics Designing Safer Chemicals | greener alternative product characteristics Waste Prevention |
Application
4-Chloro-DL-phenylalanine has been used:
- as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish[1]
- to induce insomnia in rat models[2]
- used to treat embryos to examine its effect on serotonin[3]
- for the selection of Enterococcus faecalis transformants with pESentA32 plasmid[4]
- to feed flies to explore serotonin effect[5]
Biochem/physiol Actions
4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.[6]
Tryptophan hydroxylase inhibitor.
General description
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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In silico analysis and experimental validation of lignan extracts from kadsura longipedunculata for potential 5-HT1AR agonists
Zheng Y, et al.
PLoS ONE, 10(6), e0130055-e0130055 (2015)
Dopamine and serotonin are both required for mate-copying in Drosophila melanogaster
Monier M, et al.
Frontiers in Behavioral Neuroscience, 12(5), 334-334 (2018)
Enhancement of the antibacterial activity of an E. faecalis strain by the heterologous expression of enterocin A
Serrano-Maldonado C E and Quirasco M
Journal of Biotechnology, 283(5), 28-36 (2018)
Mariana G Fronza et al.
PloS one, 12(11), e0187445-e0187445 (2017-11-02)
A series of phenylselanyl-1H-1,2,3-triazole-4-carbonitriles with different substituents were screened for their binding affinity with serotonin transporter (SERT) and dopamine transporter (DAT) by docking molecular. 5-(4methoxyphenyl)-1-(2-(phenylselanyl)phenyl)-1H-1,2,3-triazole-4-carbonitrile (SeTACN) exhibited the best conformation with SERT even higher than fluoxetine and serotonin, suggesting a
Marcin Leszczyński et al.
Science advances, 6(33), eabb0977-eabb0977 (2020-08-28)
Broadband high-frequency activity (BHA; 70 to 150 Hz), also known as "high gamma," a key analytic signal in human intracranial (electrocorticographic) recordings, is often assumed to reflect local neural firing [multiunit activity (MUA)]. As the precise physiological substrates of BHA
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