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C6645
Cytosine β-D-arabinofuranoside hydrochloride
≥99% (HPLC), synthetic (inorganic), crystalline
Synonym(s):
Arabinosylcytosine hydrochloride, 1-(β-D-Arabinofuranosyl)cytosine hydrochloride, Ara-C hydrochloride, Arabinocytidine hydrochloride, Cytarabine hydrochloride, Cytosine arabinoside hydrochloride
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25 MG
€65.30
100 MG
€86.20
500 MG
€301.00
1 G
€513.00
5 G
€1,570.00
€65.30
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About This Item
Empirical Formula (Hill Notation):
C9H13N3O5 · HCl
CAS Number:
Molecular Weight:
279.68
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
200-713-9
MDL number:
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Product Name
Cytosine β-D-arabinofuranoside hydrochloride, crystalline
InChI key
KCURWTAZOZXKSJ-JBMRGDGGSA-N
InChI
1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1
SMILES string
Cl[H].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
biological source
synthetic (inorganic)
assay
≥99% (HPLC)
form
crystalline
mp
197-198 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless
storage temp.
2-8°C
Quality Level
Gene Information
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Related Categories
1 of 4
This Item | C1768 | M6500 | 251010 |
|---|---|---|---|
| biological source synthetic (inorganic) | biological source - | biological source synthetic (organic) | biological source - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 100 |
| assay ≥99% (HPLC) | assay ≥90% (HPLC) | assay ≥98% (titration) | assay ≥98% (HPLC) |
| form crystalline | form crystalline | form powder or crystals | form solid |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| mp 197-198 °C (lit.) | mp - | mp 67-71 °C | mp - |
Application
Cytosine β-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco′s modified eagle medium (FBS-DMEM)[1] and B27/neurobasal-A medium[2] to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.[3]
Biochem/physiol Actions
Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hi I need the insert of this product please. Can you send me please? the batch number is SLCD2059
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