E9902

Ephrin-A1/Fc Chimera from mouse

Name: Ephrin-A1/Fc Chimera from mouse
Brand: SIGMA
Price: 543 EUR

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

B61, EFL-1, LERK-1

Slide 1 of 1

Select a Size

200 μG

€543.00

Please contact Customer Service for Availability

About This Item

UNSPSC Code:

51111800

NACRES:

NA.32

MDL number:

MFCD01867530

Key Documents

View All Documentation

Product Name

Ephrin-A1/Fc Chimera from mouse, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

biological source

mouse

recombinant

expressed in NSO cells

assay

>90% (SDS-PAGE)

form

lyophilized powder

potency

0.16-10 ng/mL

mol wt

monomer calculated mol wt 46.8 kDa
50-55 kDa by SDS-PAGE (reducing)

packaging

pkg of 200 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

endotoxin, tested

UniProt accession no.

P20827

storage temp.

−20°C

Quality Level

200

Gene Information

mouse ... Efna1(13636)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	E0278	A0476	N6784
Sigma-Aldrich E9902 Ephrin-A1/Fc Chimera from mouse	Sigma-Aldrich E0278 Ephrin-A3/Fc Chimera human	Sigma-Aldrich A0476 Activin Receptor-Like Kinase 1/Fc Chimera human	Sigma-Aldrich N6784 Noggin/Fc Chimera from mouse
assay >90% (SDS-PAGE)	assay >90% (SDS-PAGE)	assay >90% (SDS-PAGE)	assay >95% (SDS-PAGE)
recombinant expressed in NSO cells	recombinant expressed in NSO cells	recombinant expressed in NSO cells	recombinant expressed in NSO cells
biological source mouse	biological source human	biological source human	biological source mouse
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
storage condition avoid repeated freeze/thaw cycles	storage condition avoid repeated freeze/thaw cycles	storage condition avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)	storage condition -

Analysis Note

The biological activity is measured by its ability to bind recombinant mouse EphA2/Fc in ELISA.

Biochem/physiol Actions

EphA1 (ephrin receptor A1) plays an essential role in development, and is involved in the guidance of axonal and cell migration in nervous system.[1] Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same.[2] It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target.[3] Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri.[4] In esophageal squamous cells, it acts as differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.[5]

Member of ephrin ligand family that binds Eph receptor tyrosine kinases (EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7 and EphB1). Involved in pattern formation and morphogenesis. Ephrin-A1 can be detected on fetal osteoblasts, odotoblasts, chondrocytes, and squamous epithelium. Ephrin-A1 is expressed during embryonic vasculogenesis and during tumor-induced angiogenesis.

Other Notes

Extracellular domain of mouse ephrin-A1 (amino acids 1-182) fused to the C-terminal 6X histidine-tagged Fc region of human IgG.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation.

Matthieu Chavent et al.

Biochemistry, 53(42), 6641-6652 (2014-10-07)

EphA1 is a receptor tyrosine kinase (RTK) that plays a key role in developmental processes, including guidance of the migration of axons and cells in the nervous system. EphA1, in common with other RTKs, contains an N-terminal extracellular domain, a

EphrinA1-Fc attenuates myocardial ischemia/reperfusion injury in mice.

Augustin DuSablon et al.

PloS one, 12(12), e0189307-e0189307 (2017-12-14)

EphrinA1, a membrane-bound receptor tyrosine kinase ligand expressed in healthy cardiomyocytes, is lost in injured cells following myocardial infarction. Previously, we have reported that a single intramyocardial injection of chimeric ephrinA1-Fc at the time of ischemia reduced injury in the

Effect of EPHA1 genetic variation on cerebrospinal fluid and neuroimaging biomarkers in healthy, mild cognitive impairment and Alzheimer's disease cohorts.

Hui-Fu Wang et al.

Journal of Alzheimer's disease : JAD, 44(1), 115-123 (2014-09-04)

Ephrin type-A receptor 1 (EPHA1) (11771145) was documented to be one of the most strongly associated locus with Alzheimer's disease (AD) in a recent meta-analysis of five genome wide association studies. However, its contribution to the pathogenesis of AD remains

Lack of ephrin receptor A1 is a favorable independent prognostic factor in clear cell renal cell carcinoma.

Marieta I Toma et al.

PloS one, 9(7), e102262-e102262 (2014-07-16)

The EPH receptor tyrosine kinases and their cell-bound ligands, the ephrins, have been shown to be associated with cancer development and progression. In this study, mRNA and protein expression of the receptors EPHA1 and EPHA2 as well as of their

Increased expression of EphA1 protein in prostate cancers correlates with high Gleason score.

Libo Peng et al.

International journal of clinical and experimental pathology, 6(9), 1854-1860 (2013-09-17)

The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases regulates a multitude of physiological and pathological processes. EphA1 is the first member of Eph superfamily and is involved in carcinogenesis. The aim of this study was to investigate the expression

View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service